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2024
TBA
Ushimaru, R., Mori, T., et al.
manuscript in revision (2024) Link | Press Release
TBA
Mori, T., et al.
manuscript in revision (2024) Link | Press Release
TBA
Awakawa, T., Mori, T., Ushimaru, U., et al.
Nature Catalysis, 7, in revision (2024) Link | Press Release
TBA
Ushimaru, R., et al.
manuscript in preparation (2024) Link
TBA
Mori, T., et al.
manuscript in preparation (2024) Link
Biosynthesis of enfumafungin-type antibiotic reveals an unusual enzymatic fusion pattern and unprecedented C-C bond cleavage
Cao, Z.-Q., Wang, G.-Q., Luo, R., Gao, Y.-H., Lv, J.-M., Qin, S.-Y., Chen, G.-D., Awakawa, T., Bao, X.-F., Mei, Q.-H., Yao, X.-S., Hu, D., Abe, I., Gao, H.
J. Am. Chem. Soc., 146, in press (2024) Link
TBA
Li, S., et al.
Nature Commun., 15, in revision (2024) Link | Open Access
Discovery of (±)-penindolenes reveals an unusual indole ring cleavage pathway catalyzed by P450 monooxygenase
Meng, L.-H.,# Awakawa, T.,# Li, X.-M., Quan, Z., Yang, S.-Q., Wang, B.-G., Abe, I. (#equall contribution)
Angew. Chem. Int. Ed., 63, in revision (2024) Link | Open Access
Characterization of aziridine-forming α-Ketoglutarate-dependent oxygenase in L-isovaline biosynthesis
Zhou, L., Awakawa, T., Ushimaru, R., Kanaida, M., Abe, I.
Org. Lett., 26, 724-727 (2024) Link
TBA
Hoshino, S., Onaka, H., Abe, I.
Nat. Prod. Rep., 41, in preparation (2024) Link
TBA
Yu, Z., Abe, I.
J. Biol. Chem., in preparation (2024) Link
Unusual cysteine modifications in natural product biosynthesis
Gao, Y., Zhu, Y., Awakawa, T., Abe, I.
RSC Chem. Biol., 5, 293-311 (2024) Link | Open Access
Lincosamide antibiotics; structure, activity, and biosynthesis
Mori, T., Abe, I.
ChemBioChem, 25, e202300840 (2024) Link
Recent developments in the enzymatic modifications of steroid scaffolds
Wang, H., Abe, I.
Org. Biomol. Chem., 22, in revision (2024) Link
Functional analysis of an α-ketoglutarate-dependent non-heme iron oxygenase in fungal meroterpenoid biosynthesis
Tao, H., Abe, I.
Methods in Enzymology, 704, in revision (2024) Link
Functions and mechanisms of enzymes assembling lignans and norlignans
Ushimaru, R.
Curr. Opi. Chem. Biol., in press (2024) Link
Characterization of enzymes catalyzing unusual C–C bond formation and cleavage reactions during natural product biosynthesis
Ushimaru, R.
Chem. Pharm. Bull., 72, in press (2024) Link | Open Access
Three-membered ring formation catalyzed by α-ketoglutarate-dependent nonheme iron enzymes
Ushimaru, R.
J. Nat. Med., 78, 21-32 (2024) Link | Open Access
TBA
阿部郁朗
有機合成化学協会誌, 82, in preparation (2024) Link
奨励賞受賞 牛丸理一郎氏の業績
阿部郁朗
ファルマシア, 60, in press (2024) Link
2023
Molecular basis for carrier protein-dependent amide bond formation in the biosynthesis of lincosamide antibiotics
Mori, T.,# Kadlcik, S.,# Lyu, S.,# Kamenik, Z., Sakurada, K., Mazumdar, A., Wang, H., Janata, J., Abe, I. (#equall contribution)
Nature Catalysis, 6, 531-542 (2023) Link | Open Access | Press Release | Behind the paper
Back-to-back cycloadditions in nature
Ushimaru, R., Abe, I.
Nature Chemistry, 15, 1056–1057 (2023) Link
Mechanistic analysis of the stereodivergent nitroalkane cyclopropanation catalyzed by nonheme iron enzymes
Ushimaru, R., Cha, L., Shimo, S., Li, X., Paris, J., Mori, T., Miyamoto. K., Coffer, L., Uchiyama, M., Guo, Y., Chang, W-c., Abe, I.
J. Am. Chem. Soc., 145, 24210-24217 (2023) Link
Structural and mechanistic insights into the C–C bond forming rearrangement reaction catalyzed by heterodimeric hinokiresinol synthase
Ushimaru, R., Ding, Y., Mori, T., Miyamoto, K., Uchiyama, M., Abe, I.
J. Am. Chem. Soc., 145, 21966-21973 (2023) Link
Multiple C–C bond cleavage reactions catalyzed by tolyporphin tetrapyrrole biosynthetic enzymes
Ushimaru, R.,# Lyu, J.,# Ling, M., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 145, 9834-9839 (2023) Link
Assembling neuroactive alkaloids
Ushimaru, R., Abe, I.
Nature Plants, 9, 1946-1947 (2023) Link
Structure-function analysis of the S-glycosylation reaction in lincosamide antibiotics biosynthesis
Mori, T., Sun, X., Kadlcik, S., Janata, J., Abe, I.
Angew. Chem. Int. Ed., 62, e202304989 (2023) Link | VIP Paper | Open Access
Catalytic mechanism of non-glycosidic C-N bond formation by the pseudoglycosyltransferase enzyme VldE
Tsunoda, T., Abuelizz, H., Samadi, A., Wong, C. P., Awakawa, T., Brumsted, C., Abe, I., Mahmud, T.
ACS Catalysis, 13, 13369-13382 (2023) Link
Unusual dioxygen-dependent reactions catalyzed by nonheme iron enzymes in natural product biosynthesis
Ushimaru, R., Abe, I.
ACS Catalysis, 13, 1045-1076 (2023) Link
C–N and C–S bond formation by cytochrome P450 enzymes
Ushimaru, R., Abe, I.
Trends in Chemistry, 5, 526-536 (2023) Link
Genomic and spectroscopic signature-based discovery of natural macrolactams
Shin, Y.-H., Im,, J. H., Kang, I., Kim, E., Jang, S. C., Cho, E., Shin, D., Hwang, S. Du, Y. E., Huynh, T.-H., Ko, K., Ko, Y.-J., Nam, S.-J., Awakawa, T., Lee, J., Hong, S., Abe, I., Moore, B. S., Fenical, W., Yoon, Y. J., Cho, J.-C., Lee, S. K., Oh, K.-B., Oh, D.-C.
J. Am. Chem. Soc., 145, 1886-1896 (2023) Link
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis
Awakawa, T., Mori, T., Ushimaru, R., Abe, I.
Nat. Prod. Rep., 46-61 (2023) Link
Diverse enzymatic chemistry for propionate side chain cleavages in tetrapyrrole biosynthesis
Ushimaru, R., Lyu, J., Abe, I.
J. Ind. Microbiol. Biotechnol., 50, Article number: kuad016 (2023) Link | Open Access
Photoinduced reductive dehalogenation of phenacyl bromides with pyridoxal-5′-phosphate
Ueno, K., Ushimaru, R., Abe, I.
Chem. Pharm. Bull., 71, 675-677 (2023) Link | Open Access
Orthoester formation in fungal meroterpenoid austalide F biosynthesis
Awakawa, T., Liu, W., Bai, T., Taniguchi, T., Abe, I.
Phil. Trans R. Soc. B, 378, 20220037 (2023) Link | Open Access
Functional analysis of fungal P450 enzymes
Mori, T., Abe, I.
Methods in Enzymology, 693, 171-190 (2023) Link
Oxidative modification of free-standing amino acids by Fe(II)/αKG-dependent oxygenases
Tao, H., Abe, I.
Engineering Microbiology, 3, 100062 (2023) Link | Open Access | Special Issue
Functions, structures, and engineering of the teleocidin biosynthetic enzymes
Mori, T.
Chem. Pharm. Bull., 71, 188-197 (2023) Link | Open Access
放線菌由来生物活性二次代謝産物の生合成研究
阿部郁朗
日本放線菌学会誌会報, 37, 3-9 (2023) Link
学術振興賞受賞 森田洋行氏の業績
阿部郁朗
ファルマシア, 59, 440 (2023) Link
腸内細菌由来天然薬物C-配糖体活性化酵素の構造解析
森貴裕, 阿部郁朗
高度化するクライオ電子顕微鏡ハンドブック, エヌ・ティー・エス, 11章 205-212 (2023) Link
これからの天然物化学に向けて
森貴裕, 牛丸理一郎
月刊 ファインケミカル, 51, 5-10 (2023) Link
2022
Discovery of non-squalene triterpenes
Tao, H.,# Lauterbach, L.,# Bian, G.,# Chen, R.,# Hou, A.,# Mori, T.,# Cheng, S., Hu, B., Lu, L., Mu, X., Li, M., Adachi, N., Kawasaki, M., Moriya, T., Senda, T., Wang, X., Deng, Z., Abe, I.,* Dickschat, J. S.,* Liu, T.* (#equall contribution)
Nature, 606, 414-419 (2022) Link | Open Access | Press Release | Press Release 2 | Faculty Opinions
Stereoselectivity and substrate specificity of the Fe(II)/α-ketoglutarate-dependent oxygenase TqaL
Tao, H.,# Ushimaru, R.,# Awakawa, T., Mori, T., Uchiyama, M., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 144, 21512-21520 (2022) Link
Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/α-ketoglutarate-dependent oxygenase SptF
Tao, H.,# Mori, T.,# Chen, H., Lyu, S., Nonoyama, A., Lee, S., Abe, I. (#equall contribution)
Nature Commun., 13, Article number: 95 (2022) Link | Open Access | Behind the paper
Noncanonical functions of enzyme cofactors as building blocks in natural product biosynthesis
Barra, L., Awakawa, T., Abe, I.
JACS Au, 2, 1950-1963 (2022) Link | Open Access
Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood
Wang, X.-H., Gao, B.-W., Nakashima, Y., Mori, T., Zhang, Z.-X., Kodama, T., Lee, Y.-E., Zhang, Z.-K., Wong, C.-P., Liu, Q.-Q., Qi, B.-W., Wang, J., Li, J., Liu, X., Abe, I., Morita, H., Tu, P.-F., Shi, S.-P.
Nature Commun., 13, Article number: 348 (2022) Link | Open Access | Press Release | NC Focus
Characterization of enzymes catalyzing the initial steps of the β-lactam tabtoxin biosynthesis
Lyu, J., Ushimaru, R., Abe, I.
Org. Lett., 24, 3337-3341 (2022) Link
Structure-based redesign of Fe(II)/2-oxoglutarate-dependent oxygenase AndA to catalyze spiro-ring formation
Mori, T., Nakashima, Y., Chen, H., Hoshino, S. Mitsuhashi, T., Abe, I.
Chem. Commun., 58, 5510-5513 (2022) Link
Rational engineering of the non-heme iron- and 2-oxoglutarate-dependent oxygenase SptF
Mori, T., Yu, Z., Tao, H., Abe, I.
Org. Lett., 24, 1737-1741 (2022) Link
Cordycicadins A–D, antifeedant polyketides from the entomopathogenic fungus Cordyceps cicadae JXCH1
Li, X., Chen, H.-P., Zhou, L., Fan, J., Awakawa, T., Mori, T., Ushimaru, R., Abe, I., Liu, J.-K.
Org. Lett., 24, 8627–8632 (2022) Link
A multifunctional cytochrome P450 and a meroterpenoid cyclase in the biosynthesis of fungal meroterpenoid atlantinone B
Qi, B.-W., Li, N., Zhang, B.-B., Zhang, Z.-K., Wang, W.-J., Liu, X., Wang, J., Awakawa, T., Tu, P.-F., Abe, I., Shi, S.-P., Li, J.
Org. Lett., 24, 2526-2530 (2022) Link
Biosynthesis of dihydroxyardeemin by heterologous expression
Zhou, L., Abe, I., Awakawa, T.
Tetrahedron, 127, 133095 (2022) Link
Harnessing Fe(II)/α-ketoglutarate-dependent oxygenases for structural diversification of fungal meroterpenoids
Tao, H., Abe, I.
Curr. Opi. Biotechnol., 77, 102763 (2022) Link
Structure, function, and engineering of plant polyketide synthases
Mori, T., Nakashima, Y., Morita, H., Abe, I.
Methods in Enzymology, 676, 3-48 (2022) Link
Structural basis for endoperoxide-forming oxygenases
Mori, T., Abe, I.
Beilstein J. Org. Chem., 18, 707-721 (2022) Link | Open Access
Understanding and manipulating assembly line biosynthesis by heterologous expression in Streptomyces
Zhang, L., Awakawa, T., Abe, I.
Methods in Molecular Biology, 2489, 223-238 (2022) Link
Engineered biosynthesis of microbial medicinally active compounds
Takayoshi Awakawa
YAKUGAKU ZASSHI, 142, 347-353 (2022) Link
奨励賞受賞 森貴裕氏の業績
阿部郁朗
ファルマシア, 58, 480 (2022) Link
創薬のための新たなデバイス： iChip
阿部郁朗
次世代医薬とバイオ医療, 東京化学同人, 第11章, pp. 241-244 (2022) Link
補酵素NADを基質とする新奇の二次代謝生合成酵素の発見
淡川孝義, 阿部郁朗
バイオサイエンスとインダストリー, 80, 311-313 (2022) Link
補酵素NADを基質とする天然医薬品活性化合物の生合成機構の解明
淡川孝義
ファルマシア, 58, 1125-1129 (2022) Link
「飛翔する若手研究者」天然物の三員環骨格をつくる鉄酵素の機能解析
牛丸理一郎
化学と工業, 75, 820 (2022) Link
2021
β-NAD as a building block in natural product biosynthesis
Barra, L.,# Awakawa, T.,# Shirai, K., Hu, Z., Bashiri, G., Abe, I. (#equall contribution)
Nature, 600, 754-758 (2021) Link | Press Release | Behind the paper | Faculty Opinions
Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI
Mori, T.,# Zhai, R.,# Ushimaru, R., Matsuda, Y., Abe, I. (#equall contribution)
Nature Commun., 12, Article number: 4417 (2021) Link | Open Access | Press Release | Behind the paper | Faculty Opinions
Heterodimeric non-heme iron enzymes in fungal meroterpenoid biosynthesis
Li, X.,# Awakawa, T.,# Mori, T., Ling, M., Hu, D., Wu, B., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 143, 21425-21432 (2021) Link
Stereodivergent nitrocyclopropane formation during biosynthesis of belactosins and hormaomycins
Shimo, S.,# Ushimaru, R.,# Engelbrecht, A., Harada, M., Miyamoto, K., Andreas, K., Uchiyama, M., Kaysser, L., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 143, 18413-18418 (2021) Link
C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes
Mori, T.,# Kumano, T.,# He, H.,# Watanabe, S., Senda, M., Moriya, T., Adachi, N., Hori, S., Terashita, Y., Kawasaki, M., Hashimoto, Y., Awakawa, T., Senda, T., Abe, I., Kobayashi, M. (#equall contribution)
Nature Commun., 12, Article number: 6294 (2021) Link | Open Access
Aziridine formation by a Fe(II)/α-ketoglutarate dependent oxygenase and 2-aminoisobutyrate biosynthesis in fungi
Bunno, T.,# Awakawa, T.,# Mori, T., Abe, I. (#equall contribution)
Angew. Chem. Int. Ed., 60, 15827-15831 (2021) Link | Hot Paper
One polyketide synthase, two distinct products: trans-acting enzyme-controlled product divergence in calbistrin biosynthesis
Tao, H., Mori, T., Wei, X., Matsuda, Y., Abe, I.
Angew. Chem. Int. Ed., 60, 8851–8858 (2021) Link | VIP Paper | Cover | Press Release
Structural basis for isomerization reactions in fungal tetrahydroxanthone biosynthesis and diversification
Yang, J.,# Mori, T.,# Wei, X., Matsuda, Y., Abe, I. (#equall contribution)
Angew. Chem. Int. Ed., 60, 19458-19465 (2021) Link | Hot Paper
Insights into phosphatase-activated chemical defense in a marine sponge holobiont
Jomori, T., Matsuda, K., Egami, Y., Abe, I., Takai, A., Wakimoto, T.
RSC Chem. Biol., 2, 1600-1607 (2021) Link | Open Access
Chemistry of fungal meroterpenoid cyclases
Barra, L., Abe, I.
Nat. Prod. Rep., 38, 566-585 (2021) Link
Enzymatic formation of indolactam scaffold by C-N bond-forming cytochrome P450 oxidases in teleocidin biosynthesis
Morita, I.,# Mori, T.,# Abe, I. (#equall contribution)
Chem. Eur. J., 27, 2963-2972 (2021) Link | Frontispiece | Reviews Showcase
Enzymology and biosynthesis of the orcellinic acid derived medicinal fungal meroterpenoids
Tao, H., Abe, I.
Curr. Opi. Biotechnol., 69, 52-59 (2021) Link
Biosynthesis of alkyne-containing natural products
Li, X., Lv, J.-M., Hu, D., Abe, I.
RSC Chem. Biol., 2, 166-180 (2021) Link | Open Access | Editors' Choice
Extensive expanding the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy
Song, X.-J., Lv, J.-M., Cao, Z.-Q., Huang, H.-Y., Chen, G.-D., Awakawa, T., Hu, D., Gao, H., Abe, I., Yao, X.-S.
Acta Pharm. Sinica B, 11, 1676-1685 (2021) Link | Open Access
Amide bond formation using 4-coumarate:CoA ligase from Arabidopsis thaliana
Mori, T., Wanibuchi, K., Morita, H., Abe, I.
Chem. Pharm. Bull., 69, 717-720 (2021) Link
Novel cyclohexyl meroterpenes produced by combinatorial biosynthesis
Jiang, J., Li, X., Mori, T., Awakawa, T., Abe, I.
Chem. Pharm. Bull., 69, 444-446 (2021) Link | Featured Article
Reconstituted biosynthesis of fungal natural products in Aspergillus oryzae
Awakawa, T., Abe, I.
Journal of Fungi, 7, Article number: 486 (2021) Link | Open Access
Biosynthesis of sulfonamide and sulfamate antibiotics in Actinomycete
Awakawa, T., Barra, L., Abe, I.
J. Ind. Microbiol. Biotechnol., 48, Article number: kuab001 (2021) Link | Open Access
Microbial soluble aromatic prenyltransferases for engineered biosynthesis
Chen, H., Abe, I.
Synth. Syst. Biotechnol., 6, 51-62 (2021) Link | Open Access
Shanpanootols A-F, diterpenoids from the rhizomes of Kaempferia pulchra collected in Myanmar and their Vpr inhibitory activity
Win, N. N., Kodama, T., Htoo, Z. P., Hnin, S. Y. Y., Ngwe, H., Abe, I., Morita, H.
Fitoterapia, 151, 104870 (2021) Link
Shanpanootols G and H, diterpenoids from the rhizomes of Kaempferia pulchra collected in Myanmar and their Vpr inhibitory activity
Win, N. N., Kodama, T., Htoo, Z. P., Hnin, S. Y. Y., Ngwe, H., Abe, I., Morita, H.
Chem. Pharm. Bull., 69, 913-917 (2021) Link
Pyrrolactams from marine sponge Stylissa massa collected from Myanmar and their anti-Vpr activities
Win, N. N., Kodama, T., Aye, A. A., Ngwe, H., Han, N. M., Abe, I., Morita, H.
Chem. Pharm. Bull., 69, 702-705 (2021) Link
Anti-Vpr activities of sesqui- and diterpenoids from the roots and rhizomes of Kaempferia candida
Prema, Kodama, T., Nyunt, H. H. W., Ngwe, H., Abe, I., Morita, H.
J. Nat. Med., 75, 489-498 (2021) Link
A new monoterpene isolated from the rhizomes of Alpinia galanga and its anti-Vpr activity
Hoan, N. N., Kodama, T., Win N. N., Prema, Do, K. M., Abe, I., Morita, H.
Chem. Biodivers., 18, e2100401 (2021) Link
Engineered biosynthesis of pharmaceutically important compounds
Awakawa, T.
Chem. Pharm. Bull., 69, 415-420 (2021) Link | Open Access
The enzymatic reactions in teleocidin B biosynthesis
Awakawa, T.
J. Nat. Med., 75, 467-474 (2021) Link | Open Access
Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold
Basler, S., Studer, S., Zou, Y., Mori, T., Ota, Y., Camus, A., Bunzel, H. A., Helgeson, R. C., Houk, K. N., Jiménez-Osés, G., Hilvert, D.
Nature Chemistry, 13, 231–235 (2021) Link
学術振興賞受賞 脇本敏幸氏の業績
阿部郁朗
ファルマシア, 57, 420 (2021) Link
期待の若手
牛丸理一郎
ファルマシア, 57, 665 (2021) Link
芳香族化合物
阿部郁朗
パートナー天然物化学 改訂第４版, 南江堂, 第３章 (2021)
アルカロイドおよびそのほかの含窒素化合物
淡川孝義
パートナー天然物化学 改訂第４版, 南江堂, 第５章 (2021)
2020
Heterochiral coupling in non-ribosomal peptide macrolactamization
Matsuda, K., Zhai, R., Mori, T., Kobayashi, M., Sano, A., Abe, I., Wakimoto, T.
Nature Catalysis, 3, 507-515 (2020) Link | Press Release | Press Release 2 | News & Views | Behind the paper
Exploiting the potential of meroterpenoid cyclases to expand the chemical space of fungal meroterpenoids
Mitsuhashi, T.,# Barra, L.,# Powers, Z.,# Kojasoy, V.,# Cheng, A., Yang, F., Taniguchi, Y., Kikuchi, T., Fujita, M., Tantillo, D. J., Porco, J. A. Jr., Abe, I. (#equall contribution)
Angew. Chem. Int. Ed., 59, 23772-23781 (2020) Link | Hot Paper
Exploiting a C-N bond forming cytochrome P450 monooxygenase for C-S bond formation
Morita, I.,# Mori, T.,# Mitsuhashi, T.,# Hoshino, S.,# Taniguchi, Y., Kikuchi, T., Nagae, K., Nasu, N., Fujita, M., Ohwada, T., Abe, I. (#equall contribution)
Angew. Chem. Int. Ed., 59, 3988-3993 (2020) Link | Hot Paper | Frontispiece
Acyltransferase that catalyses the condensation of polyketide and peptide moieties of goadvionin hybrid lipopeptides
Kozakai, R., Ono, T., Hoshino, S., Takahashi, H., Katsuyama, Y., Sugai, Y., Ozaki, T., Teramoto, K., Teramoto, K., Tanaka, K., Abe, I., Asamizu, S., Onaka, H.
Nature Chemistry, 12, 869–877 (2020) Link | Press Release | Press Release 2
Biosynthesis of biscognienyne B involving an unprecedented cytochrome P450-dependent alkynylation
Lv, J.-M., Gao, Y.-H., Zhao, H., Awakawa, T., Liu, L., Chen, G.-D., Yao, X.-S., Hu, D., Abe, I., Gao, H.
Angew. Chem. Int. Ed., 59, 13531-13536 (2020) Link
Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases
He, H.,# Bian, G.,# Herbst-Gervason, C. J.,# Mori, T., Shinsky, S. A., Hou, A., Mu, X., Huang, M., Cheng, S., Deng, Z., Christianson, D. W., Abe, I., Liu, T. (#equall contribution)
Nature Commun., 11, Article number: 3958 (2020) Link | Open Access | Press Release | Press Release 2 | NC Focus
Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea
Zhang, Y.-H., Li, Y.-F., Wang, Y., Tan, L., Cao, Z.-Q., Xie, C., Xie, G., Gong, H.-B., Sun, W.-Y., Ouyang, S.-H., Duan, W.-J., Lu, X., Ding, K., Kurihara, H., Hu, D., Zhang, Z.-M., Abe, I., He, R.-R.
Nature Commun., 11, Article number: 1473 (2020) Link | Open Access
Structural diversification of andiconin-derived natural products by α-ketoglutarate-dependent dioxygenases
Bai, T., Matsuda, Y., Tao, H., Mori, T., Zhang, Y., Abe, I.
Org. Lett., 22, 4311–4315 (2020) Link
Sporormielones A–E, bioactive novel C-C coupled orsellinic acid derivative dimers, and their biosynthetic origin
Chen, G., Hu, D., Huang, M.-J., Tang, J., Wang, X.-X., Zou, J., Xie, J., Zhang, W.-G., Guo, L.-D., Yao, X.-S., Abe, I., Gao, H.
Chem. Commun., 56, 4607-4610 (2020) Link
Deciphering the biosynthetic mechanism of pelletierine in Lycopodium alkaloid biosynthesis
Wang, J., Zhang, Z.-K., Jiang, F.-F., Qi, B.-W., Ding, N., Hnin, S. Y. Y., Liu, X., Li, J., Wang, X.-H., Tu, P.-F., Abe, I., Morita, H., Shi, S.-P.
Org. Lett., 22, 8725-8729 (2020) Link
Total synthesis and structural revision of kasumigamide, and identification of a new analogue
Kuranaga, T., Matsuda, K., Takaoka, M., Tachikawa, C., Sano, A., Itoh, K., Enomoto, A., Fujita, K., Abe, I., Wakimoto, T.
ChemBioChem, 21, 3329 – 3332 (2020) Link
Molecular basis for sesterterpene (C25) diversity produced by plant terpene synthases
Chen, Q., Li, J., Liu, Z., Mitsuhashi, T., Zhang, Y., Liu, H., Ma, Y., He, J., Shinada, T., Sato, T., Wang, Y., Liu, H., Abe, I., Zhang, P., Wang, G.
Plant Commun., 1, Article number: 100051 (2020) Link | Open Access
Fungal meroterpenoids
Matsuda, Y., Abe, I.
Comprehensive Natural Products III: Chemistry and Biology, Vol. 1, Elsevier, Chapter 14, pp. 445-478 (2020) Link
Overview and introduction
Abe, I., Tang, Y., Townsend, C.
Comprehensive Natural Products III: Chemistry and Biology, Vol. 1, Elsevier, Chapter 1, pp. 1-3 (2020) Link
Hapalindoles
Awakawa, T., Liu, X.
Comprehensive Natural Products III: Chemistry and Biology, Vol. 2, Elsevier, Chapter 18, pp. 486-499 (2020) Link
Sesterterpenoids
Mitsuhashi, T., Abe, I.
Progress in the Chemistry of Organic Natural Products, Vol. 111, Springer, pp. 1-79 (2020) Link
α-Ketoglutarate-dependent enzyme AndA involved in anditomin biosynthesis
Nakashima, Y., Mori, T., Abe, I.
Encyclopedia of Inorganic and Bioinorganic Chemistry, Wiley, DOI: 10.1002/9781119951438.eibc2735 (2020) Link
Nonheme iron- and 2-oxoglutarate-dependent dioxygenases in fungal meroterpenoid biosynthesis
Abe, I.
Chem. Pharm. Bull., 68, 823-831 (2020) Link | Featured Article | Open Access
Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases
Abe, I.
J. Nat. Med., 74, 639-646 (2020) Link | Open Access
Three new quassinoids isolated from the wood of Picrasma javanica and their anti-Vpr activities
Prema, Wong, C. P., Kodama, T., Nugroho, A. E., El-Desoky, A. H., Awouafack, M. D., Win, Y. Y., Ngwe, H., Abe, I., Morita, H., Morita, H.
J. Nat. Med., 74, 571–578 (2020) Link
Anti-Vpr activities of homodrimane sesquiterpenoids and labdane diterpenoids from Globba sherwoodiana rhizomes
Prema, Kodama, T., Wong, C. P., El-Desoky, A. H., Awouafack, M. D., Nyunt, H. H. W., Ngwe, H., Abe, I., Morita, H.
Fitoterapia, 146, 104705 (2020) Link
Enzymatic studies on aromatic prenyltransferases
Mori, T.
J. Nat. Med., 74, 501–512 (2020) Link | Open Access
Engineered artificial carboligases facilitate regioselective preparation of enantioenriched aldol adducts
Macdonald, D. S., Garrabou, X., Klaus, C., Verez, R., Mori, T., Hilvert, D.
J. Am. Chem. Soc., 144, 10250-10254 (2020) Link
Expansion of gamma-butyrolactone signaling molecule biosynthesis to phosphotriester natural products
Kudo, Y., Awakawa, T., Du, Y.-L., Jordan, P. A., Creamer, K. E., Jensen, P. R., Linington, R. G., Ryan, K. S., Moore, B. S.
ACS Chem. Biol., 15, 3253–3261 (2020) Link
奨励賞受賞 淡川孝義氏の業績
阿部郁朗
ファルマシア, 56, 570 (2020) Link
2019
Molecular basis for the P450-catalyzed C–N bond formation in indolactam biosynthesis
He, F.,# Mori, T.,# Morita, I.,# Nakamura, H., Alblova, M., Hoshino, S., Awakawa, T., Abe, I. (#equall contribution)
Nature Chem. Biol., 15, 1206-1213 (2019) Link | Open Access | Press Release
Aminoacyl sulfonamide assembly in SB-203208 biosynthesis
Hu, Z.,# Awakawa, T.,# Ma, Z., Abe, I. (#equall contribution)
Nature Commun., 10, Article number: 184 (2019) Link | Open Access | Press Release
Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum: branched pathways encoded at two separate loci
Araki, Y.,# Awakawa, T.,# Matsuzaki, M.,# Cho, R., Matsuda, Y., Hoshino, S., Shinohara, Y., Yamamoto, M., Kido, Y., Inaoka, D. K., Nagamune, K., Ito, K., Abe, I., Kita, K. (#equall contribution)
Proc. Natl. Acad. Sci. USA, 116, 8269-8274 (2019) Link | Open Access | Press Release
Biomimetic synthesis of meroterpenoids by dearomatization-driven polycyclization
Powers, Z., Scharf, A., Yang, F., Cheng, A., Mitsuhashi, T., Barra, L., Taniguchi, Y., Kikuchi, T., Fujita, M., Abe, I., Porco, J. A. Jr.
Angew. Chem. Int. Ed., 58, 16141-16146 (2019) Link
Structural elucidation of tenebrathin: cytotoxic C-5-substituted γ-pyrone with nitroaryl side chain from Streptoalloteichus tenebrarius
Hoshino, S., Mitsuhashi, T., Kikuchi, T., Wong, C. P., Morita, H., Awakawa, T., Fujita, M., Abe, I.
Org. Lett., 21, 6519-6522 (2019) Link
A multidomain P450 epoxidase and a terpene cyclase from ascochlorin biosynthetic pathway in Fusarium sp.
Quan, Z.,# Awakawa, T.,# Wang, D.,# Hu, Y., Abe, I. (#equall contribution).
Org. Lett., 21, 2330–2334 (2019) Link
(+)- and (-)-Preuisolactone A: a pair of caged norsesquiterpenoidal enantiomers with a tricyclo[4,4,01,6,02,8]decane carbon skeleton from the endophytic fungus Preussia isomera
Xu, L.-L., Chen, H.-L., Hai, P., Gao, Y., Xie, C.-D., Yang, X.-L., Abe, I.
Org. Lett., 21, 1078-1081 (2019) Link
How structural subtleties lead to molecular diversity for the type III polyketide synthases
Morita, H., Wong, C. P., Abe, I.
J. Biol. Chem., 294, 15121-15136 (2019) Link | Open Access | JBC Thematic Series
Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity
Cao, Z.-Q., Li, S.-Y., Lv, J.-M., Gao, H., Chen, G.-D., Awakawa, T., Abe, I., Yao, X.-S., Hu, D.
Acta Pharm. Sinica B, 9, 433-442 (2019) Link | Open Access
Fe(II)/α-ketoglutarate-dependent dioxygenase PrhA
Mori, T., Abe, I.
Encyclopedia of Inorganic and Bioinorganic Chemistry, Wiley, DOI: 10.1002/9781119951438.eibc2695 (2019) Link
The molecular basis for the plasticity of the aromatic prenyltransferases in hapalindole biosynthesis
Awakawa, T., Abe, I.
Beilstein J. Org. Chem., 15, 1545-1551 (2019) Link | Open Access
Inherent atomic mobility changes in carbocation intermediates during the sesterterpene cyclization cascade
Sato, H., Mitsuhashi, T., Yamazaki, M., Abe, I., Uchiyama, M.
Beilstein J. Org. Chem., 15, 1890-1897 (2019) Link | Open Access
Activation of silent biosynthetic pathways and discovery of novel secondary metabolites in actinomycetes by co-culture method using mycolic acid-containing bacteria
Hoshino, S., Onaka, H., Abe, I.
J. Ind. Microbiol. Biotechnol., 46, 363-374 (2019) Link
Beijinchromes A-D, novel aromatic compounds isolated from Nocardia beijingensis NBRC 16342
Hoshino, S., Awakawa, T., Zhang, H., Hayashi, F., Abe, I.
Chem. Pharm. Bull., 67, 775-777 (2019)Link
Bis-iridoid and iridoid glucosides: viral protein R inhibitors from Picrorhiza kurroa collected in Myanmar
Win, N. N., Kodama, T., Lae, K. Z. W., Win, Y. Y., Ngwe, H., Abe, I., Morita, H.
Fitoterapia, 134, 101-107 (2019) Link
Lignans with melanogenesis effects from Premna serratifolia wood
Woo, S.-Y., Hoshino, S., Wong, C. P., Win, N. N., Awouafack, M. D., Prema, P., Ngwe, H., Zhang, H., Hayashi, F., Abe, I., Morita, H.
Fitoterapia, 133, 35-42 (2019) Link
Viral protein R inhibitors from Swertia chirata of Myanmar
Win, N. N., Oo, W. M. N., Woo, S. Y., Ito, T., Ngwe, H., Abe, I., Morita, H.
J. Biosci. Bioeng., 128, 445-449 (2019) Link
A new tetrahydrofuran type lignan from Premna integrifolia wood
Woo, S.-Y., Wong, C. P., Win, N. N., Hoshino, S., Prema, Ngwe, H., Abe, I., Morita, H.
Nat. Prod. Commun., 14, 113-116 (2019) Link
Dinorcassane diterpenoid from Boesenbergia rounda rhizomes collected in Lower Myanmar
Win N.N., Kyaw M.M., Prema, Ngwe H., Ito T., Asakawa Y., Okamoto Y., Tanaka M., Abe, I., Morita, H.
Chem. Biodivers., 16, e1800657 (2019) Link
Involvement of β-alkylation machinery and two sets of ketosynthase–chain length factors in the biosynthesis of fogacin polyketides in Actinoplanes missouriensis
Sato, K., Katsuyama, Y., Yokota, K., Awakawa, T., Tezuka, T., Ohnishi, Y.
ChemBioChem, 20, 1106-1114 (2019) Link
Exploitation and application of unique actinomycetical alkaloid biosynthetic enzymes
Awakawa, T.
Actinomycetologica, 33, S3-S8 (2019) Link
生合成マシナリーの合理的再構築による次世代天然物化学
阿部郁朗
ファルマシア, 55, 645-649 (2019) Link
アスコフラノンの選択的大量生産系の構築～アフリカ睡眠病の根絶を目指して～
荒木康子, 淡川孝義, 松崎素道, 阿部郁朗
バイオサイエンスとインダストリー, 77, 466-468 (2019)
2018
Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis
Nakashima, Y., Mori, T., Nakamura, H., Awakawa, T., Hoshino, S., Senda, M., Senda, T., Abe, I.
Nature Commun., 9, Article number: 104 (2018) Link | Open Access | Press Release
Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
Awakawa, T., Fujioka, T., Zhang, L., Hoshino, S., Hu, Z., Hashimoto, J., Kozone, I., Ikeda, H., Shin-ya, K., Liu, W., Abe, I.
Nature Commun., 9, Article number: 3534 (2018) Link | Open Access | Press Release
Structural and computational bases for dramatic skeletal rearrangement in anditomin biosynthesis
Nakashima, Y.,# Mitsuhashi, T.,# Matsuda, Y.,# Senda, M., Sato, H., Yamazaki, M., Uchiyama, M., Senda, T., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 140, 9743-9750 (2018) Link
Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation
Matsuda, Y., Bai, T., Phippen, C. B. W., Nødvig, C. S., Kjærbølling, I., Vesth, T. C., Andersen, M. R., Mortensen, U. H., Gotfredsen, C. H., Abe, I., Larsen, T. O.
Nature Commun., 9, Article number: 2587 (2018) Link | Open Access | Behind the paper | Faculty of 1000
Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
Wang, G.-Q., Chen, G.-D., Qin, S.-Y., Hu, D., Awakawa, T., Li, S.-Y., Lv, J.-M., Wang, C.-X., Yao, X.-S., Abe, I., Gao, H.
Nature Commun., 9, Article number: 1838 (2018) Link | Open Access | Press Release | NC Collection
Molecular insights into the Mg2+-dependent allosteric control of indole prenylation by aromatic prenyltransferase AmbP1
Awakawa, T., Mori, T., Nakashima, Y., Zhai, R., Wong, C. P., Hillwig, M. L., Liu, X., Abe, I.
Angew. Chem. Int. Ed., 57, 6810-6813 (2018) Link
Two distinct substrate binding modes for the normal and reverse prenylations of hapalindoles by the prenyltransferase AmbP3
Wong, C. P.,# Awakawa, T.,# Nakashima, Y., Mori, T., Zhu, Q., Liu, X., Abe, I. (#equall contribution)
Angew. Chem. Int. Ed., 57, 560-563 (2018) Link
Computational studies on biosynthetic carbocation rearrangements leading to quiannulatene: initial conformation regulates biosynthetic route, stereochemistry, and type of skeleton
Sato, H., Mitsuhashi, T., Yamazaki, M., Abe, I., Uchiyama, M.
Angew. Chem. Int. Ed., 57, 14752-14757 (2018) Link
Elucidation and heterologous reconstitution of chrodrimanin B biosynthesis
Bai, T.,# Quan, Z.,# Zhai, R., Awakawa, T., Matsuda, Y., Abe, I. (#equall contribution)
Org. Lett., 20, 7504-7508 (2018) Link
The crystalline sponge method enabled the investigation of a prenyl-transferase-terpene synthase chimeric enzyme, whose product exhibits broadened NMR signals
Mitsuhashi, T., Kikuchi, T., Hoshino, S., Ozeki, M., Awakawa, T., Shi, S.-P., Fujita, M., Abe, I.
Org. Lett., 20, 5606-5609 (2018) Link
Unique chemistry of non-heme iron dependent enzymes in fungal biosynthetic pathway
Nakamura, H., Matsuda, Y., Abe, I.
Nat. Prod. Rep., 35, 633-645 (2018) Link | Front Cover
Catenulobactins A and B, heterocyclic peptides from culturing Catenuloplanes sp. with mycolic acid-containing bacterium
Hoshino, S., Ozeki, M., Awakawa, T., Morita, H., Onaka, H., Abe, I.
J. Nat. Prod., 81, 2106-2110 (2018) Link
Hinduchelins A–D, noncytotoxic catechol derivatives from Streptoalloteichus hindustanus
He, F., Nakamura, H., Hoshino, S., Chin, J. S. F., Yang, L., Zhang, H.-P., Hayashi, F., Abe, I.
J. Nat. Prod., 81, 1493–1496 (2018) Link
Biosynthesis of the teleocidin-type terpenoid indole alkaloids
Awakawa, T., Abe, I.
Org. Biomol. Chem., 16, 4737–4916 (2018) Link | Front Cover
Chimeric terpene synthases possessing both terpene cyclization and prenyltransfer activities
Mitsuhashi T., Abe, I.
ChemBioChem, 19, 1106-1114 (2018) Link
A tryptophan prenyltransferase with broad substrate tolerance from Bacillus subtilis subsp. natto
Sugita, T., Okada, M., Nakashima, Y., Tian, T., Abe, I.
ChemBioChem, 19, 1396-1399 (2018) Link
Biosynthetic studies on teleocidins in Streptomyces
Abe, I.
J. Antibiot., 71, 763-768 (2018) Link
Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp. and mycolic acid-containing bacterium
Hoshino, S., Wong, C. P., Ozeki, M., Zhang, H., Hayashi, F., Awakawa, T., Asamizu, S., Onaka, H., Abe, I.
J. Antibiot., 71, 653-657 (2018) Link
Mirilactams C-E, novel polycyclic macrolactams isolated from combined-culture of Actinosynnema mirum NBRC 14064 and mycolic acid-containing bacterium
Hoshino, S., Ozeki, M., Wong, C. P., Zhang, H., Hayashi, F., Awakawa, T., Morita, H., Onaka, H., Abe, I.
Chem. Pharm. Bull., 66, 660-667 (2018) Link | Highlighted Paper
Tetrahydrofuran lignans: Melanogenesis inhibitors from Premna integrifolia wood collected in Myanmar
Win, N. N., Woo, S.-Y., Ngwe, H., Prema, Wong, C. P., Ito, T., Okamoto, Y., Tanaka, M., Imagawa, H., Asakawa, Y., Abe, I., Morita, H.
Fitoterapia, 127, 308-313 (2018) Link
Two new pyrrolo-2-aminoimidazoles, Clathriroles A and B, from marine sponge, Clathria prolifera collected in Myanmar
Woo, S.-Y., Win, N. N., Wong, C. P., Ito, T., Hoshino, S., Ngwe, H., Aye, A. A., Han, N., Zhang, H., Hayashi, F., Abe, I., Morita, H.
J. Nat. Med., 72, 803-807 (2018) Link
A non-canonical proximal heme ligand affords an efficient peroxidase in a globin fold
Edwardson, T. G. W., Mori, T., Hilvert, D.
J. Am. Chem. Soc., 140, 10349-10442 (2018) Link
A non-canonical proximal heme ligand affords an efficient peroxidase in a globin fold
Pott, M., Hayashi, T., Mori, T., Mittl, P. R. E., Green, A. P., Hilvert, D.
J. Am. Chem. Soc., 140, 1535-1543 (2018) Link
Rational engineering of a designed protein cage for siRNA delivery
Niquille, D. L., Hansen, D. A., Mori, T., Fercher, D., Kries, H., Hilvert, D.
Nature Chemistry, 9, 282-287 (2018) Link
Capture and characterisation of a reactive haem-carbenoid complex in an artificial metalloenzyme
Hayashi, T., Tinzl, M., Mori, T., Krengel, U., Proppe, J., Soetbeer, J., Klose, D., Jeschke, G., Reiher, M., Hilvert D.
Nature Catalysis, 1, 578-584 (2018) Link
Total enzyme syntheses of napyradiomycins A1 and B1
McKinnie, S. M. K., Miles, Z. D., Jordan, P. A., Awakawa, T., Pepper, H. P., Murray, L. A. M., George, J. H., Moore, B. S.
J. Am. Chem. Soc., 140, 17840–17845 (2018) Link
酵素の立体構造を基盤にした新規生体触媒の開発、
森貴裕, 阿部郁朗
化学, 73, 32-36 (2018) Link
多段階反応を触媒する酸化酵素のエンジニアリング
中嶋優, 阿部郁朗
現代化学, 567, 17-21 (2018) Link
テルペンインドールアルカロイドテレオシジンの生合成反応
淡川孝義
有機合成化学協会誌, 76, 410-413 (2018) Link
2017
Molecular basis for the unusual ring reconstruction in fungal meroterpenoid biogenesis
Mori, T., Iwabuchi, T., Hoshino, S., Wang, H., Matsuda, Y., Abe, I.
Nature Chem. Biol., 13, 1066-1073 (2017) Link | Press Release
Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis
Lv, J.-M., Hu, D., Gao, H., Kushiro, T., Awakawa, T., Chen, G.-D., Wang, C.-X., Abe, I., Yao, X.-S.
Nature Commun., 8, Article number: 1644 (2017) Link | Open Access | Press Release | NC Collection
Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides
Zhang, L., Hashimoto, T., Qin, B., Hashimoto, J., Kozone, I., Kawahara, T., Okada, M., Awakawa, T., Ito, T., Asakawa, Y., Ueki, M., Takahashi, S., Osada, H., Wakimoto, T., Ikeda, H., Shin-ya, K., Abe, I.
Angew. Chem. Int. Ed., 56, 1740-1745 (2017) Link | Hot Paper | Frontispiece | Press Release
Mechanistic characterization of two chimeric sesterterpene synthases from Penicillium
Mitsuhashi, T.,# Rinkel, J.,# Okada, M., Abe, I., Dickschat, J. S. (#equall contribution)
Chem. Eur. J., 23, 10053-10057 (2017) Link
Mycolic acid-containing bacterium stimulates tandem cyclization of polyene macrolactam in a lake sediment-derived rare actinomycete
Hoshino, S., Okada, M., Awakawa, T., Asamizu, S., Onaka, H., Abe, I.
Org. Lett., 19, 4992-4995 (2017) Link
Identification of chimeric αβγ diterpene synthases possessing both type II terpene cyclase and prenyltransferase activities
Mitsuhashi, T., Okada, M., Abe, I.
ChemBioChem, 18, 2104-2109 (2017) Link | Very Important Paper | Cover Picture
Combinatorial biosynthesis of (+)-daurichromenic acid and its halogenated analogue
Okada, M., Saito, K., Wong, C. P., Li, C., Wang, D., Iijima, M., Taura, F., Kurosaki, F., Awakawa, T., Abe, I.
Org. Lett., 19, 3183-3186 (2017) Link
2-Alkylquinolone alkaloid biosynthesis by collaboration of two novel type III polyketide synthases in Evodia rutaecarpa
Matsui, T., Kodama, T., Mori, T., Tadakoshi, T., Noguchi, H., Abe, I., Morita, H.
J. Biol. Chem., 292, 9117-9135 (2017) Link
Identification of pyridinium with three indole moieties as an antimicrobial agent
Okada, M., Sugita,T., Wong, C. P., Wakimoto, T., Abe, I.
J. Nat. Prod., 80, 1205-1209 (2017) Link
Posttranslational isoprenylation of tryptophan in bacteria
Okada, M., Sugita, T., Abe, I.
Beilstein J. Org. Chem., 13, 338-346 (2017) Link
Identification and characterization of daurichromenic acid synthase active in anti-HIV biosynthesis
Iijima, M., Munakata, R., Takahashi, H., Kenmoku, H., Nakagawa, R., Kodama, T., Asakawa, Y., Abe, I., Yazaki, K., Kurosaki, F., Taura, F.
Plant Physiol., 174, 2213-2230 (2017) Link
3,5-Dimethylorsellinic acid derived meroterpenoids from Penicillium chrysogenum MT-12, an endophytic fungus isolated from Huperzia serrata
Qi, B., Liu, X., Mo, T., Zhu, Z., Li, J. Wang, J., Shi, X., Zeng, K., Wang, X., Tu, P., Abe, I., Shi, S.
J. Nat. Prod., 80, 2699-2707 (2017) Link
Labdane diterpenoids from Curcuma amada rhizomes collected in Myanmar and their antiproliferative activities
Win, N. N, Ito, T., Ngwe, H., Win, Y. Y., Prema, Okamoto, Y., Tanaka, M., Asakawa, Y., Abe, I., Morita, H.
Fitoterapia, 32, 34-39 (2017) Link
Naturally occurring Vpr inhibitors from medicinal plants of Myanmar
Win, N. N., Ngwe, H., Abe, I., Morita, H.
J. Nat. Med., 71, 579-589 (2017) Link
Bifunctionality of ActIV as a cyclase-thioesterase revealed by in vitro reconstitution of actinorhodin biosynthesis in Streptomyces coelicolor A3(2)
Taguchi, T.,# Awakawa, T.,# Nishihara, Y., Kawamura, M., Ohnishi, Y., Ichinose, K. (#equall contribution)
ChemBioChem, 18, 316-323 (2017) Link
Enzymatic C-H amidation in the production of natural and unnatural thiotetronate antibiotics with potentiated bioactivity
Li, J., Tang, X., Awakawa, T., Moore, B. S.
Angew. Chem. Int. Ed., 56, 12234-12239 (2017) Link
A new strategy for aromatic ring alkylation in cylindrocyclophane biosynthesis
Nakamura, H., Schultz, E. E., Balskus, E. P.
Nature Chem. Biol., 13, 916-921 (2017) Link
Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality
Amos, G. C., Awakawa, T., Letzel, A., Kim, M. C., Kudo, Y., Tuttle, R. N., Fenical, W., Moore, B. S., Jensen, P. R.
Proc. Natl. Acad. Sci. USA, 114, E11121–E11130 (2017) Link
微生物由来テルペンインドールアルカロイド-テレオシジン生合成
淡川孝義, 阿部郁朗
アルカロイドの化学, 化学同人, 第７章, pp. 134-148 (2017)
納豆のネバネバを誘導する修飾ペプチドフェロモンの構造
岡田正弘, 阿部郁朗
バイオサイエンスとインダストリー, 75, 508-511 (2017)
2016
Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases
Mori, T., Zhang, L., Awakawa, T., Hoshino, S., Okada, M., Morita, H., Abe, I.
Nature Commun., 7, Article number: 10849 (2016) Link | Open Access | Press Release
Structural insight into the enzymatic formation of bacterial stilbene
Mori, T., Awakawa, T., Shimomura, K., Saito, Y., Yang, D., Morita, H., Abe, I.
Cell Chem. Biol., 23, 1468-1479 (2016) Link | Preview
Discovery of key dioxygenases that diverged the paraherquonin and acetoxydehydroaustin pathways in Penicillium brasilianum
Matsuda, Y.,# Iwabuchi,T.,# Fujimoto, T., Awakawa,T., Nakashima, Y., Mori, T., Zhang, H., Hayashi, F., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 138, 12671-12677 (2016) Link
Genome-based discovery of an unprecedented cyclization mode in fungal sesterterpenoids biosynthesis
Okada, M.,# Matsuda, Y.,# Mitsuhashi, T., Hoshino, S., Mori, T., Nakagawa, K., Quan, Z., Qin, B., Zhang, H., Hayashi, F., Kawaide, H., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 138, 10011-10018 (2016) Link | JACS Spotlights
Astellifadiene, a unique tetracyclic fungal sesterterpene: structure determination by an NMR-coupled crystalline sponge method and elucidation of its biosynthesis
Matsuda, Y.,# Mitsuhashi,T.,# Lee, S.,# Hoshino, M., Mori, T., Okada, M., Zhang, H., Hayashi, F., Fujita, M., Abe, I. (#equall contribution)
Angew. Chem. Int. Ed., 55, 5785-5788 (2016) Link
An unusual chimeric diterpene synthase from Emericella variecolor and its functional conversion to a sesterterpene synthase by domain swapping
Qin, B.,# Matsuda, Y.,# Mori, T., Okada, M., Quan, Z., Mitsuhashi, T., Wakimoto, T., Abe, I. (#equall contribution)
Angew. Chem. Int. Ed., 55, 1658-1661 (2016) Link | Front Cover | Press Release
Engineering of Candida glabrata Ketoreductase 1 for asymmetric reduction of α-halo ketones
Qin, F., Qin, B., Mori, T., Wang, Y., Meng, L., Zhang, X., Jia, Z., Abe, I., You, S.
ACS Catalysis, 6, 6135-6140 (2016) Link
Metagenomic analysis of the sponge Discodermia reveals the production of the cyanobacterial natural product kasumigamide by 'Entotheonella'
Nakashima, Y., Egami, Y., Kimura, M., Wakimoto, T., Abe, I.
PLoS ONE, 11(10): e0164468 (2016) Link | Open Access
Biosynthesis of fungal meroterpenoids
Matsuda, Y., Abe, I.
Nat. Prod. Rep., 33, 26-53 (2016) Link | Open Access
Nature's way of making the sponge-derived cytotoxin
Wakimoto, T., Egami, Y., Abe, I.
Nat. Prod. Rep., 33, 751-760 (2016) Link | Open Access | Front Cover
Unusual chemistries in fungal meroterpenoid biosynthesis
Matsuda, Y., Awakawa, T., Mori, T., Abe, I.
Curr. Opin. Chem. Biol., 31, 1-7 (2016) Link
Cytochrome P450 for citreohybridonol synthesis: oxidative derivatization of andrastin scaffold
Matsuda, Y.,# Quan, Z.,# Mitsuhashi, T., Li, C., Abe, I. (#equall contribution)
Org. Lett., 18, 296-299 (2016) Link
Stereospecific prenylation of tryptophan by a cyanobacterial post-translational modification enzyme
Okada, M., Sugita, T., Akita, K., Nakashima, Y., Tian, T., Li, C., Mori, T., Abe, I.
Org. Biomol. Chem., 14, 9639-9644 (2016) Link | Open Access
Sulfoureido lipopeptides from the marine sponge Discodermia kiiensis
Tan, K. C., Wakimoto, T., Abe, I.
J. Nat. Prod., 79, 2418–2422 (2016) Link
Structural diversification of lyngbyatoxin A by host-dependent heterologous expression of the tleABC biosynthetic gene cluster
Zhang, L., Hoshino, S., Awakawa, T., Wakimoto, T., Abe, I.
ChemBioChem, 17, 1407-1411 (2016) Link
Biosynthesis of LL-Z1272β: discovery of a new member of NRPS-like enzymes for aryl-aldehyde formation
Li, C., Matsuda, Y., Gao, H., Hu, D., Yao, X. S., Abe, I.
ChemBioChem, 17, 904-907 (2016) Link
Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa
Yang, X., Matsui, T., Kodama, T., Mori, T., Zhou, X., Taura, F., Noguchi, H., Abe, I., Morita, H.
FEBS J., 283, 1088-1106 (2016) Link
Myanmarnicins H−M: new quassinoids from Picrasma javanica collected in Myanmar and their antiproliferative activities
Win, N. N., Ito, T., Ismail, Kodama, T., Win, Y. Y., Tanaka, M., Okamoto, Y., Imagawa, H., Ngwe, H., Asakawa, Y., Abe, I., Morita, H.
Tetrahedron, 72, 746-752 (2016) Link
Isopimarane diterpenoids from Kaempferia pulchra rhizomes collected in Myanmar and their Vpr inhibitory activity
Win, N. N., Ito, T., Matsui, T., Aimaiti, S., Kodama, T., Ngwe, H., Okamoto, Y., Tanaka, M., Asakawa, Y., Abe, I., Morita, H.
Bioorg. Med. Chem. Lett., 26, 1789-1793 (2016) Link
Quassinoids: viral protein R inhibitors from Picrasma javanica bark collected in Myanmar for HIV infection
Win, N. N., Ito, T., Win, Y. Y., Ngwe, H., Kodama, T., Abe, I., Morita, H.
Bioorg. Med. Chem. Lett., 26, 4620-4624 (2016) Link
Effective production of aromatic polyketides in Streptomyces bacteria using combined-culture method
Hoshino, S., Okada, M., Onaka, H., Abe, I.
Nat. Prod. Commun., 11, 979-981 (2016) Link
Insight into the aroma profile of Bulgarian tobacco absolute oil
Nedeltcheva-Antonovaa, D., Ivanovaa, D., Antonova, L., Abe, I.
Industrial Crops and Products, 94, 226-232 (2016) Link
生合成の新しい設計図を書く
阿部郁朗
実験医学, 羊土社, 34, 2746-2747 (2016)
結晶構造を基盤とした天然物の生合成酵素工学
森貴裕, 阿部郁朗
化学工業, 67, 56-61 (2016)
海綿共生微生物による生物活性物質の生産
江上蓉子, 脇本敏幸, 阿部郁朗
バイオインダストリー, 33, 11-17 (2016)
芳香族化合物
阿部郁朗
パートナー天然物化学 改訂第３版, 南江堂, 第３章 (2016)
2015
Uncovering the unusual D-ring construction in terretonin biosynthesis by collaboration of a multifunctional cytochrome P450 and a unique isomerase
Matsuda, Y.,# Iwabuchi, T.,# Wakimoto, T., Awakawa, T., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 137, 3393-3401 (2015) Link
Rational control of polyketide extender units by structure-based engineering of a crotonyl-CoA carboxylase/reductase in antimycin biosynthesis
Zhang, L., Mori, T., Zheng, Q., Awakawa, T., Yan, Y., Liu, W., Abe, I.
Angew. Chem. Int. Ed., 54, 13462-13465 (2015) Link | Press Release | Faculty of 1000
Structural basis for the β-carboline alkaloids production by the microbial homodimeric enzyme McbB
Mori, T., Hoshino, S., Sahashi, S., Wakimoto, T., Matsui, T., Morita, H., Abe, I.
Chemistry & Biology, 22, 898-906 (2015) Link | Preview
Structural basis for the formation of acylalkylpyrones from two β-ketoacyl units by the fungal type III polyketide synthase CsyB
Mori, T., Yang, D., Matsui, T, Hashimoto, M., Morita, H., Fujii, I., Abe, I.
J. Biol. Chem., 290, 5214-5225 (2015) Link
Molecular basis for stellatic acid biosynthesis: a genome mining approach for discovery of sesterterpene synthases
Matsuda, Y.,# Mitsuhashi, T.,# Quan, Z., Abe, I. (#equall contribution)
Org. Lett., 17, 4644-4647 (2015) Link
Chojalactones A-C, cytotoxic butanolides isolated from Streptomyces sp. cultivated with mycolic acid containing bacterium
Hoshino, S., Wakimoto, T., Onaka, H., Abe, I.
Org. Lett., 17, 1501-1504 (2015) Link
Niizalactams A-C, multicyclic macrolactams isolated from combined-culture of Streptomyces sp. with mycolic acid containing bacterium
Hoshino, S., Okada, M., Wakimoto, T., Zhang, H., Hayashi, F., Onaka, H., Abe, I.
J. Nat. Prod., 78, 3011-3017 (2015) Link
Production of indole antibiotics induced by exogenous gene derived from sponge metagenome
Takeshige, Y., Egami, Y., Wakimoto, T., Abe, I.
Mol. BioSyst., 11, 1290-1294 (2015) Link
Dietziamides, novel tetramic acid dimers from Dietzia timorensis MZ-3 with antioxidative activity
Hoshino, S., Wakimoto, T., Zhang, H., Hayashi, F., Okada, M., Abe, I.
Bioorg. Med. Chem. Lett., 25, 3953-3955 (2015) Link
Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823
Hoshino, S., Zhang, L., Awakawa, T., Wakimoto, T., Onaka, H., Abe, I.
J. Antibiot., 68, 342-344 (2015) Link
Myanmarnicins A−G, quassinoids from Picrasma javanica collected in Myanmar
Win, N. N., Ito, T., Ismail, Kodama, T., Win, Y. Y., Tanaka, M., Ngwe, H., Asakawa, Y., Abe, I., Morita, H.
J. Nat. Prod., 78, 3024-3030 (2015) Link
Kaempulchraols P−T, diterpenoids from the Kaempferia pulchra rhizomes collected in Myanmar
Win, N. N., Ito, T., Aimaiti, S., Kodama, T., Tanaka, M., Ngwe, H., Asakawa, Y., Abe, I., Morita, H.
J. Nat. Prod., 78, 2306-2309 (2015) Link
Diterpenes kaempulchraols A−J from the rhizomes of Kaempferia pulchra of Myanmar and their antiproliferative activity
Win, N. N., Ito, T., Aimaiti, S., Imagawa, H., Ngwe, H., Abe, I., Morita, H.
J. Nat. Prod., 78, 1113-1118 (2015) Link
Kaempulchraols I−O: New isopimarane diterpenoids from the rhizomes of Kaempferia pulchra collected in Myanmar and their antiproliferative activity
Win, N. N., Ito, T., Aimaiti, S., Kodama, T., Imagawa, H., Ngwe, H., Asakawa, Y., Abe, I., Morita, H.
Tetrahedron, 71, 4707-4713 (2015) Link
Very-long-chain 3-hydroxy fatty acids, 3-hydroxy fatty acid methyl esters and 2-alkanols from cuticular waxes of Aloe arborescens leaves
Racovita, R. C., Peng, C., Awakawa, T., Abe, I., Jetter, R.
Phytochemistry, 113, 183-194 (2015) Link
Crystallization and preliminary X-ray diffraction analysis of a plant polyketide cyclase from Cannabis sativa
Yang, X., Matsui, T., Mori, T., Taura, F., Noguchi, H., Abe, I., Morita, H.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 71, 1470-1474 (2015) Link
Salinipyrone and pacificanone are biosynthetic byproducts of the rosamicin polyketide synthase
Awakawa, T., Cruesemann, M., Munguia, J., Ziemert, N., Nizet V., Fenical, W., Moore, B. S.
ChemBioChem, 16, 1443-1447 (2015) Link
Chemoenzymatic synthesis of acyl coenzyme A substrates enables in situ labeling of small molecules and proteins
Agarwal, V., Diethelm, S., Ray, L., Garg, N., Awakawa, T., Dorrestein, P. C., Moore, B. S.
Org. Lett., 17, 4452-4455 (2015) Link
Cytotoxic cyclic peptides from the marine sponges
Wakimoto, T., Tan, K. C., Tajima, H., Abe, I.
Handbook of Anticancer Drugs from Marine Origin, Springer, Chapter 6, pp. 113-144 (2015) Link
海綿ー共生微生物系の化学防御機構
脇本敏幸, 江上蓉子, 阿部郁朗
化学と生物, 53, 497-499 (2015)
海綿動物の化学防御を担う共生細菌
江上蓉子, 脇本敏幸, 阿部郁朗
細胞工学, 34, 412-416 (2015)
カイメンー共生バクテリア系の化学防御機構
脇本敏幸, 阿部郁朗
バイオサイエンスとインダストリー, 73, 49-51 (2015)
自然が誇るデザイナー、酸化酵素の生み出す多彩な分子骨格
松田侑大, 阿部郁朗
化学, 70, 66-67 (2015)
ゲノム情報に基づいた天然物生産の試み
阿部郁朗
第二次先端ウォッチング：天然物化学研究の最前線、生合成とケミカルバイオロジーの新展開，日本化学会, pp.25-29 (2015)
2014
Complete biosynthetic pathway of anditomin: nature's sophisticated synthetic route to a complex fungal meroterpenoid
Matsuda, Y., Wakimoto, T., Mori, T., Awakawa, T., Abe, I.
J. Am. Chem. Soc., 136, 15326–15336 (2014) Link | Front Cover | JACS Spotlights
Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont
Wakimoto, T.,# Egami, Y.,# Nakashima, Y., Wakimoto,Y., Mori, T., Awakawa,T., Ito, T., Kenmoku, H., Asakawa, Y., Piel, J., Abe, I. (#equall contribution)
Nature Chem. Biol., 10, 648-655 (2014) Link | News & Views | Press Release | Faculty of 1000
A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis
Awakawa, T., Zhang, L., Wakimoto, T., Hoshino, S., Mori, T., Ito, T., Ishikawa, J., Tanner, M. E., Abe, I.
J. Am. Chem. Soc., 136, 9910-9913 (2014) Link | Faculty of 1000
An environmental bacterial taxon with a large and distinct metabolic repertoire
Wilson, M. C., Mori, T., Rückert, C., Uria, A. R., Helf, M. J., Takada, K., Gernert, C., Steffens, U. A. E., Heycke, N., Schmitt, S., Rinke, C., Helfrich, E. J. N., Brachmann, A. O., Gurgui, C., Wakimoto. T., Kracht, M., Crüsemann, M., Hentschel, U., Abe, I., Matsunaga, S., Kalinowski, J., Takeyama, H., Piel, J.
Nature, 506, 58-62 (2014) Link | Open Access | News & Views | Press Release
Lipodiscamides A-C, new cytotoxic lipopeptides from the marine sponge Discodermia kiiensis
Tan, K. C., Wakimoto, T., Abe, I.
Org. Lett., 16, 3256-3259 (2014) Link
Three acyltetronic acid derivatives: noncanonical cryptic polyketides from Aspergillus niger identified by genome mining
Yang, X.-L., Awakawa, T., Wakimoto, T., Abe, I.
ChemBioChem, 15, 1578-1583 (2014) Link
Revised structure of cyclolithistide A, a cyclic depsipeptide from the marine sponge Discodermia japonica
Tajima, H., Wakimoto, T., Takada, K., Ise, Y., Abe, I.
J. Nat. Prod., 77, 154-158 (2014) Link
Phosphocalyculin C as a pyrophosphate protoxin of calyculin C in the marine sponge Discodermia calyx
Egami, Y., Wakimoto, T., Abe, I.
Bioorg. Med. Chem. Lett., 24, 5150-5153 (2014) Link
Expression, purification, and crystallization of a fungal type III polyketide synthase that produces the csypyrones
Yang, D., Mori, T., Matsui, T., Hashimoto, M., Morita, H., Fujii, I., Abe, I.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 70, 730-733 (2014) Link
Crystallization and preliminary X-ray diffraction analysis of AntE, a crotonyl-CoA carboxylase/reductase from Streptomyces sp. NRRL 2288
Zhang, L., Chen, J., Mori, T., Yan, Y., Liu, W., Abe, I.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 70, 734-737 (2014) Link
Meroterpenoids
Matsuda, Y., Abe, I.
Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Springer, Chapter 13, pp. 289-301 (2014) Link
The oxidosqualene cyclases: one substrate, diverse products
Abe, I.
Natural Products: Discourse, Diversity and Design, Wiley, Chapter 16, pp. 297-316 (2014) Link
生合成工学による創薬
阿部郁朗
ファルマシア, 50, 509-511 (2014)
植物ポリケタイド合成酵素の機能制御による非天然型化合物生産
淡川孝義, 森 貴裕, 阿部郁朗
生物工学会誌, 92, 420-423 (2014)
2013
Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis
Matsuda, Y., Awakawa, T., Wakimoto, T., Abe, I.
J. Am. Chem. Soc., 135, 10962-10965 (2013) Link
Cloning and structure-function analyses of quinolone- and acridone-producing novel type III polyketide synthases from Citrus microcarpa
Mori, T., Shimokawa, Y., Matsui, T., Kinjo, K., Kato, R., Noguchi, H., Sugio, S., Morita, H., Abe, I.
J. Biol. Chem., 288, 28845-28858 (2013) Link
Multiplexing of combinatorial chemistry in antimycin biosynthesis expands the molecular diversity and utility
Yan Y., Chen, J., Zhang, L., Zheng, Q., Han, Y., Zhang, H., Awakawa, T., Abe, I., Liu, W.
Angew. Chem. Int. Ed., 52, 12308-12312 (2013) Link | Press Release
Pyranonigrin E: a novel PKS-NRPS hybrid metabolite from Aspergillus niger identified by genome mining
Awakawa, T., Yang, X.-L., Wakimoto, T., Abe, I.
ChemBioChem, 14, 2095-2099 (2013) Link
Reconstituted biosynthesis of fungal meroterpenoid andrastin A
Matsuda, Y., Awakawa, T., Abe, I.
Tetrahedron, 69, 8199-8204 (2013) Link
Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii
Tan, K. C., Wakimoto, T., Takada, K., Ohtsuki, T., Uchiyama, N., Goda, Y., Abe, I.
J. Nat. Prod., 76, 1388-1391 (2013) Link
Ergot alkaloid from the sea slug Pleurobranchus forskalii
Wakimoto, T., Tan, K. C., Abe, I.
Toxicon, 72, 1-4 (2013) Link
FK506 maturation involves a cytochrome P450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation
Chen, D., Zhang, L., Pang, B., Chen, J., Xu, Z., Abe, I., Liu, W.
J. Bacteriol., 195, 1931-1939 (2013) Link
Induced production of the novel glycolipid ustilagic acid C in the plant pathogen Ustilago maydis
Yang, X.-L., Awakawa, T., Wakimoto, T., Abe, I.
Tet. Lett., 54, 3655-3657 (2013) Link
Induced production of novel prenyldepside and coumarins in endophytic fungi Pestalotiopsis acaciae
Yang, X.-L., Awakawa, T., Wakimoto, T., Abe, I.
Tet. Lett., 54, 5814-5817 (2013) Link
Indole-porphyrin hybrids produced by metagenomics
Yang, X.-L., Wakimoto, T., Takeshige, Y., He, R., Egami, Y., Abe, I.
Bioorg. Med. Chem. Lett., 23, 3810-3813 (2013) Link
Induced biosyntheses of a novel butyrophenone and two aromatic polyketides in the plant pathogen Stagonospora nodorum
Yang, X.-L., Awakawa, T., Wakimoto, T., Abe, I.
Nat. Prod. Bioprospect., 3, 141-144 (2013) Link
Epigenetic modifier-induced biosynthesis of novel fusaric acid derivatives in endophytic fungi from Datura stramonium L.
Chen, H., Awakawa, T., Sun, J., Wakimoto, T., Abe, I.
Nat. Prod. Bioprospect., 3, 20-23 (2013) Link
Replacement of a quinone by a 5-O-acetylhydroquinone abolishes accidental necrosis-inducing effect while preserving apoptosis-inducing effect of renieramycin M in lung cancer cells
Cheun-Arom, T., Chanvorachote, P., Sirimangkalakitti, N., Chuanasa, T., Saito, N., Abe, I., Suwanborirux, K.
J. Nat. Prod., 76, 1468-1474 (2013) Link
Cyclodipeptides from metagenomic library of a Japanese marine sponge
He, R., Wang, B., Wakimoto, T., Wang, M., Zhu, L., Abe, I.
J. Braz. Chem. Soc., 24, 1926-1932 (2013) Link
3-Methyl-6-(3'-oxoalkan-2'-yl)-2-pyrone syntheses by a type III polyketide synthase from Rhodospirillum centenum
Awakawa, T., Sugai, Y., Otsutomo, K., Ren, S., Masuda, S., Katsuyama, Y., Ohnishi, Y., Horinouchi, S.
ChemBioChem, 14, 1006-1013 (2013) Link
糸状菌由来メロテルペノイドの生合成研究とその応用
松田侑大, 阿部郁朗
酵素工学ニュース, 第69号, 26-30 (2013)
2012
Novel applications of plant polyketide synthases
Abe, I.
Curr. Opin. Chem. Biol., 16, 179-185 (2012) Link
Biosynthesis: an HR-PKS stereo surprise
Abe, I.
Nature Chem. Biol., 8, 322-323 (2012) Link
Engineering of plant type III polyketide synthases
Wakimoto, T., Morita, H., Abe, I.
Methods in Enzymology, 515, 337-358 (2012) Link
Prenylation of a nonaromatic carbon of indolylbutenone by a fungal indole prenyltransferase
Chen, J., Morita, H., Wakimoto, T., Mori, T., Noguchi, H., Abe, I.
Org. Lett., 14, 3080-3083 (2012) Link
Terretonin biosynthesis requires methylation as essential step for cyclization
Matsuda, Y., Awakawa, T., Itoh, T., Wakimoto, T., Kushiro, T., Fujii, I., Ebizuka, Y., Abe, I.
ChemBioChem, 13, 1738-1741 (2012) Link
Biosynthetic pathway for highly structural diversity of a common dilactone core in antimycin production
Yan, Y., Zhang, L., Ito, T., Qu, X., Asakawa, Y., Awakawa, T., Abe, I., Liu, W.
Org. Lett., 14, 4142-4145 (2012) Link
Labile natural products
Wakimoto, T., Abe, I.
MedChemComm, 3, 866-870 (2012) Link
Calyxamides A and B, cytotoxic cyclic peptides from the marine sponge Discodermia calyx
Kimura, M., Wakimoto, T., Egami, Y., Tan, K. C., Ise, Y., Abe, I.
J. Nat. Prod., 75, 290-294 (2012) Link
Allos-hemicalyculin A, a photochemically converted calyculin from the marine sponge Discodermia calyx
Kimura, M., Wakimoto, T., Abe, I.
Tet. Lett., 54, 114-116 (2012) Link
A heptaketide naphthaldehyde produced by a polyketide synthase from Nectria haematococca
Awakawa, T., Kaji, T., Wakimoto, T., Abe, I.
Bioorg. Med. Chem. Lett., 22, 4338-4340 (2012) Link
Porphyrins from a metagenomic library of the marine sponge Discodermia calyx
He, R., Wakimoto, T., Takeshige, Y., Egami, Y., Kenmoku, H., Ito, T, Wang, B., Asakawa, Y., Abe, I.
Mol. BioSyst., 6, 2334-2338 (2012) Link
Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine sponge
He, R., Wakimoto, T., Egami, Y., Kenmoku, H., Ito, T, Asakawa, Y., Abe, I.
Bioorg. Med. Chem. Lett., 22, 7322-7325 (2012) Link
Expression, purification, and crystallization of an indole prenyltransferase from Aspergillus fumigatus
Chen, J., Morita, H., Kato, R., Noguchi, H., Sugio, S., Abe, I.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 68, 355-358 (2012) Link
Molecular cloning and characterization of copper amine oxidase from Huerzia serrata
Sun, J., Morita, H., Chen, G., Noguchi, H., Abe, I.
Bioorg. Med. Chem. Lett., 22, 5784-5790 (2012) Link
Induced production of mycotoxins in an endophytic fungus from the medicinal plant Datura stramonium
Sun, J., Awakawa, T., Noguchi, H., Abe, I.
Bioorg. Med. Chem. Lett., 22, 6397-6400 (2012) Link
Benzophenone synthase from Garcinia mangostana L. Pericarp
Nualkaew, N., Morita, H., Shimokawa, Y., Kinjo K., Kushiro, T., De-Eknamkul, W., Ebizuka, Y., Abe, I.
Phytochemistry, 77, 60-69 (2012) Link
Benzalacetone synthase
Shimokawa, Y., Morita, H., Abe, I.
Frontiers in Plant Science, 3, 57 (2012) Link
Identification of a key prenyltransferase involved in biosynthesis of the most abundant fungal meroterpenoids derived from 3,5-dimethylorsellinic acid
Itoh, T., Tokunaga, K., Radhakrishnan, E. K., Fujii, I., Abe, I., Ebizuka, Y., Kushiro, T.
ChemBioChem, 13, 1132-1135 (2012) Link
Stereocontrolled total synthesis of (+)-UCS1025A
Uchida, T., Ogawa, T., Yasuda, Y., Mimura, H., Fujimoto, T., Fukuyama, T., Wakimoto, T., Asakawa, T., Hamashima, Y., Kan, T.
Angew. Chem. Int. Ed., 51, 12850-12853 (2012) Link
Enzymatic synthesis of unnatural cyclic triterpenes
Abe, I.
Isoprenoid Synthesis in Plants and Microorganisms, Springer, Chapter 27, pp. 393-403 (2012) Link
2011
Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase
Morita, H., Yamashita, M., Shi, S.-P., Wakimoto, T., Kondo, S., Kato, R., Sugio, S., Kohno, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 108, 13504-13509 (2011) Link
Cytotoxic tetramic acid derivative produced by a plant type III polyketide synthase
Wakimoto, T., Mori, T., Morita, H., Abe, I.
J. Am. Chem. Soc., 133, 4746-4749 (2011) Link
Furan fatty acid as an anti-inflammatory component from green-lipped mussel Perna canaliculus
Wakimoto, T., Kondo, H., Nii, H., Kimura, K., Egami, Y., Oka, Y., Yoshida, M., Kida, E., Ye, Y.-p., Akahoshi, S., Asakawa, T., Matsumura, K., Ishida, H., Nukaya, H., Tsuji, K., Kan, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 108, 17533-17537 (2011) Link
Crystallization and preliminary X-ray analysis of 4-coumarate:CoA ligase from Arabidopsis thaliana
Morita, H., Mori, T., Wanibuchi, K., Kato, R., Sugio, S., Abe, I.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 67, 409-411 (2011) Link
Enzymatic formation of an aromatic dodecaketide by engineered plant polyketide synthase
Wanibuchi, K., Morita, H., Noguchi, H., Abe, I.
Bioorg. Med. Chem. Lett., 21, 2083-2086 (2011) Link
Molecular cloning, modeling and site-directed mutagenesis of type III polyketide synthase from Sargassum binderi
Baharum, H., Morita, H., Tomitsuka, A., Lee, F.-C., Ng, K.-Y., Rahim, R. A., Abe, I., Ho, C.-L.
Marine Biotech., 13, 845-856 (2011) Link
Proof of the existence of an unstable amino acid, pleurocybellaziridine, in Pleurocybella porrigens (angel's wing mushroom)
Wakimoto, T., Asakawa, T., Akahoshi, S., Suzuki, T., Nagai, K., Kawagishi, H., Kan, T.
Angew. Chem. Int. Ed., 50, 1168-1170 (2011) Link
Enantioselective total synthesis of aperidine
Wakimoto, T., Miyata, K., Ohuchi, H., Asakawa, T., Nukaya, H., Suwa, Y., Kan, T.
Org. Lett., 13, 2789-2791 (2011) Link
Characterization of the biosynthesis gene cluster for alkyl-O-dihydrogeranyl-methoxyhydroquinones in Actinoplanes missouriensis
Awakawa, T., Fujita, N., Hayakawa, M., Ohnishi, Y., Horinouchi, S.
ChemBioChem, 12, 439-448 (2011) Link
植物ポリケタイド合成酵素による生物活性テトラミン酸誘導体の合成
森貴裕, 脇本敏幸, 森田洋行, 阿部郁朗
バイオサイエンスとインダストリー, 69, 308-310 (2011)
二次代謝酵素の機能制御と生合成工学
森田洋行, 阿部郁朗
化学工業, 62, 102-108 (2011)
海からの抗炎症活性物質
脇本敏幸, 阿部郁朗
薬事日報「研究戦略・YAKU学」, 第10966号, 2011年4月8日
結晶構造を基盤とした植物ポリケタイド合成酵素の触媒機能の拡張
森田洋行
酵素工学ニュース, 第66号, 6-11 (2011)
2010
A structure-based mechanism for benzalacetone synthase from Rheum palmatum
Morita, H., Shimokawa, Y., Tanio, M., Kato, R., Noguchi, H., Sugio, S., Kohno, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 107, 669-673 (2010) Link
Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa
Morita, H., Wanibuchi, K., Nii, H., Kato, R., Sugio, S., Abe, I.
Proc. Natl. Acad. Sci. USA, 107, 19778-19783 (2010) Link
Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases
Itoh, T., Tokunaga, K., Matsuda, Y., Fujii, I., Abe, I., Ebizuka, Y., Kushiro, T.
Nature Chemistry, 2, 858-864 (2010) Link | News & Views | Faculty of 1000
Alkylresorcinol synthases expressed in Sorghum bicolor root hairs play an essential role in the biosynthesis of the allelopathic benzoquinone sorgoleone
Cook, D., Rimando, A. M., Clemente, T. E., Schröder, J., Dayan, F. E., Nanayakkara, N. P. D., Pan, Z., Noonan, B. P., Fishbein, M., Abe, I., Duke, S. O., Baerson, S. R.
Plant Cell, 22, 867-887 (2010) Link
Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases
Abe, I., Morita, H.
Nat. Prod. Rep., 27, 809-838 (2010) Link | Front Cover
Enzymatic synthesis of plant polyketides
Abe, I.
Topics in Current Chemistry, 297, 45-66 (2010) Link
Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase
Kimura, M., Kushiro, T., Shibuya, M., Ebizuka, Y., Abe, I.
Biochem. Biophys. Res. Commun., 391, 899-902 (2010) Link
Expression, purification and crystallization of a plant type III polyketide synthase that produces diarylheptanoids
Morita, H., Wanibuchi, K., Kato, R., Sugio, S., Abe, I.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 66, 948-950 (2010) Link
Structure-based engineering of benzalacetone synthase
Shimokawa, Y., Morita, H., Abe, I.
Bioorg. Med. Chem. Lett., 20, 5099-5103 (2010) Link
Bacterial squalene cyclase
Abe, I.
Comprehensive Natural Products II: Chemistry and Biology, Vol. 1, Elsevier, Chapter 19, pp. 709-732 (2010) Link
Plant polyketide synthase
Morita, H., Abe, I., Noguchi, H.
Comprehensive Natural Products II: Chemistry and Biology, Vol. 1, Elsevier, Chapter 6, pp. 171-225 (2010) Link
Enzymatic synthesis of cyclic triterpenes
Kushiro, T., Abe, I.
Pentacyclic Triterpenes as Promising Agents in Cancer, Nova Publishers, Chapter 2, pp. 13-47 (2010) Link
Triterpene
Kushiro , T., Ebizuka, Y.
Comprehensive Natural Products II: Chemistry and Biology, Vol. 1, Elsevier, Chapter 18, pp. 673-708 (2010) Link
天然薬物の生合成工学
阿部郁朗
戦略的創薬科学の魅力：東京大学大学院薬学系研究科からの発信, 廣川書店，119-134 (2010)
2009
Enzymatic formation of unnatural novel chalcone, stilbene, and benzophenone scaffolds by plant type III polyketide synthase
Shi, S.-P., Wanibuchi, K., Morita, H., Endo, K., Noguchi, H. Abe, I.
Org. Lett., 11, 551-554 (2009) Link
Novel type III polyketide synthases from Aloe arborescens
Mizuuchi, Y., Shi, S.-P., Wanibuchi, K., Kojima, A., Morita, H., Noguchi, H., Abe, I.
FEBS J., 276, 2391-2401(2009) Link
Enzymatic formation of unnatural novel polyketide scaffolds by plant type III polyketide synthase
Shi, S.-P., Morita, H., Wanibuchi, K., Noguchi, H., Abe, I.
Tetrahedron Lett., 50, 2150-2153 (2009) Link
Biosynthesis of steroidal antibiotic fusidanes: functional analysis of oxidosqualene cyclase and subsequent tailoring enzymes from Aspergillus fumigatus
Mitsuguchi, H., Seshime, Y., Fujii, I., Shibuya, M., Ebizuka, Y., Kushiro, T.
J. Am. Chem. Soc., 131, 6402-6411 (2009) Link
植物ポリケタイド合成酵素研究の最前線
森田洋行, 阿部郁朗
化学と生物, 47, 772-780 (2009)
植物ポリケタイド合成酵素の生合成工学
阿部郁朗
第二次先端ウォッチング：融合領域の創製 生合成工学，日本化学会, pp. 17-20 (2009)
糸状菌メロテルペノイド骨格合成酵素の機能解析
海老塚豊, 久城哲夫
第二次先端ウォッチング：融合領域の創製 生合成工学，日本化学会, pp. 11-15 (2009)
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