Biosynthesis of enfumafungin-type antibiotic reveals an unusual enzymatic fusion pattern and unprecedented C-C bond cleavage
Cao, Z.-Q., Wang, G.-Q., Luo, R., Gao, Y.-H., Lv, J.-M., Qin, S.-Y., Chen, G.-D., Awakawa, T., Bao, X.-F., Mei, Q.-H., Yao, X.-S., Hu, D., Abe, I., Gao, H.
J. Am. Chem. Soc., 146, in press (2024) Link
Discovery of (±)-penindolenes reveals an unusual indole ring cleavage pathway catalyzed by P450 monooxygenase
Meng, L.-H.,Awakawa, T., Li, X.-M., Quan, Z., Yang, S.-Q., Wang, B.-G., Abe, I.
Angew. Chem. Int. Ed., 63, e202403963 (2024) Link | Open Access
Mechanistic analysis of the stereodivergent nitroalkane cyclopropanation catalyzed by nonheme iron enzymes
Ushimaru, R., Cha, L., Shimo, S., Li, X., Paris, J., Mori, T., Miyamoto. K., Coffer, L., Uchiyama, M., Guo, Y., Chang, W-c., Abe, I.
J. Am. Chem. Soc., 145, 24210-24217 (2023) Link
Structural and mechanistic insights into the C–C bond forming rearrangement reaction catalyzed by heterodimeric hinokiresinol synthase
Ushimaru, R., Ding, Y., Mori, T., Miyamoto, K., Uchiyama, M., Abe, I.
J. Am. Chem. Soc., 145, 21966-21973 (2023) Link
Molecular basis for carrier protein-dependent amide bond formation in the biosynthesis of lincosamide antibiotics
Mori, T., Kadlcik, S., Lyu, S., Kamenik, Z., Sakurada, K., Mazumdar, A., Wang, H., Janata, J., Abe, I.
Nature Catalysis, 6, 531-542 (2023) Link | Open Access | Press Release | Behind the paper
Structure-function analysis of the S-glycosylation reaction in lincosamide antibiotics biosynthesis
Mori, T., Sun, X., Kadlcik, S., Janata, J., Abe, I.
Angew. Chem. Int. Ed., 62, e202304989 (2023) Link | VIP Paper | Open Access
Multiple C–C bond cleavage reactions catalyzed by tolyporphin tetrapyrrole biosynthetic enzymes
Ushimaru, R., Lyu, J., Ling, M., Abe, I.
J. Am. Chem. Soc., 145, 9834–9839 (2023) Link
Catalytic mechanism of non-glycosidic C-N bond formation by the pseudoglycosyltransferase enzyme VldE
Tsunoda, T., Abuelizz, H., Samadi, A., Wong, C. P., Awakawa, T., Brumsted, C., Abe, I., Mahmud, T.
ACS Catalysis, 13, 13369-13382 (2023) Link
Unusual dioxygen-dependent reactions catalyzed by nonheme iron enzymes in natural product biosynthesis
Ushimaru, R., Abe, I.
ACS Catalysis, 13, 1045-1076 (2023) Link
C–N and C–S bond formation by cytochrome P450 enzymes
Ushimaru, R., Abe, I.
Trends in Chemistry, 5, 526-536 (2023) Link
Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis
Awakawa, T., Mori, T., Ushimaru, R., Abe, I.
Nat. Prod. Rep., 40, 46-61 (2023) Link
Stereoselectivity and substrate specificity of the Fe(II)/α-ketoglutarate-dependent oxygenase TqaL
Tao, H., Ushimaru, R., Awakawa, T., Mori, T., Uchiyama, M., Abe, I.
J. Am. Chem. Soc., 144, 21512-21520 (2022) Link
Discovery of non-squalene triterpenes
Tao, H., Lauterbach, L., Bian, G., Chen, R., Hou, A., Mori, T., Cheng, S., Hu, B., Lu, L., Mu, X., Li, M., Adachi, N., Kawasaki, M., Moriya, T., Senda, T., Wang, X., Deng, Z., Abe, I., Dickschat, J. S., Liu, T.
Nature, 606, 414-419 (2022) Link | Open Access | Press Release | Press Release 2 | Faculty Opinions
Molecular insights into the unusually promiscuous and catalytically versatile Fe(II)/α-ketoglutarate-dependent oxygenase SptF
Tao, H., Mori, T., Chen, H., Lyu, S., Nonoyama, A., Lee, S., Abe, I.
Nature Commun., 13, Article number: 95 (2022) Link | Open Access | Behind the paper
Identification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood
Wang, X.-H., Gao, B.-W., Nakashima, Y., Mori, T., Zhang, Z.-X., Kodama, T., Lee, Y.-E., Zhang, Z.-K., Wong, C.-P., Liu, Q.-Q., Qi, B.-W., Wang, J., Li, J., Liu, X., Abe, I., Morita, H., Tu, P.-F., Shi, S.-P.
Nature Commun., 13, Article number: 348 (2022) Link | Open Access | Press Release | NC Focus
Heterodimeric non-heme iron enzymes in fungal meroterpenoid biosynthesis
Li, X., Awakawa, T., Mori, T., Ling, M., Hu, D., Wu, B., Abe, I.
J. Am. Chem. Soc., 143, 21425-21432 (2021) Link
β-NAD as a building block in natural product biosynthesis
Barra, L., Awakawa, T., Shirai, K., Hu, Z., Bashiri, G., Abe, I.
Nature, 600, 754-758 (2021) Link | Press Release | Behind the paper | Faculty Opinions
Stereodivergent nitrocyclopropane formation during biosynthesis of belactosins and hormaomycins
Shimo, S., Ushimaru, R., Engelbrecht, A., Harada, M., Miyamoto, K., Andreas, K., Uchiyama, M., Kaysser, L., Abe, I.
J. Am. Chem. Soc., 143, 18413-18418 (2021) Link
Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI
Mori, T., Zhai, R., Ushimaru, R., Matsuda, Y., Abe, I.
Nature Commun., 12, Article number: 4417 (2021) Link | Open Access | Press Release | Behind the paper | Faculty Opinions
C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes
Mori, T., Kumano, T., He, H., Watanabe, S., Senda, M., Moriya, T., Adachi, N., Hori, S., Terashita, Y., Kawasaki, M., Hashimoto, Y., Awakawa, T., Senda, T., Abe, I., Kobayashi, M.
Nature Commun., 12, Article number: 6294 (2021) Link | Open Access
Structural basis for isomerization reactions in fungal tetrahydroxanthone biosynthesis and diversification
Yang, J., Mori, T., Wei, X., Matsuda, Y., Abe, I.
Angew. Chem. Int. Ed., 60, 19458-19465 (2021) Link | Hot Paper
Aziridine formation by a Fe(II)/α-ketoglutarate dependent oxygenase and 2-aminoisobutyrate biosynthesis in fungi
Bunno, T., Awakawa, T., Mori, T., Abe, I.
Angew. Chem. Int. Ed., 60, 15827-15831 (2021) Link | Hot Paper
One polyketide synthase, two distinct products: trans-acting enzyme-controlled product divergence in calbistrin biosynthesis
Tao, H., Mori, T., Wei, X., Matsuda, Y., Abe, I.
Angew. Chem. Int. Ed., 60, 8851–8858 (2021) Link | VIP Paper | Cover | Press Release
Chemistry of fungal meroterpenoid cyclases
Barra, L., Abe, I.
Nat. Prod. Rep., 38, 566-585 (2021) Link
Exploiting the potential of meroterpenoid cyclases to expand the chemical space of fungal meroterpenoids
Mitsuhashi, T., Barra, L., Powers, Z., Kojasoy, V., Cheng, A., Yang, F., Taniguchi, Y., Kikuchi, T., Fujita, M., Tantillo, D. J., Porco, J. A. Jr., Abe, I.
Angew. Chem. Int. Ed., 59, 23772-23781 (2020) Link | Hot Paper
Heterochiral coupling in non-ribosomal peptide macrolactamization
Matsuda, K., Zhai, R., Mori, T., Kobayashi, M., Sano, A., Abe, I., Wakimoto, T.
Nature Catalysis, 3, 507-515 (2020) Link | Press Release | Press Release 2 | News & Views
Acyltransferase that catalyses the condensation of polyketide and peptide moieties of goadvionin hybrid lipopeptides
Kozakai, R., Ono, T., Hoshino, S., Takahashi, H., Katsuyama, Y., Sugai, Y., Ozaki, T., Teramoto, K., Teramoto, K., Tanaka, K., Abe, I., Asamizu, S., Onaka, H.
Nature Chemistry, 12, 869–877 (2020) Link | Press Release | Press Release 2
Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases
He, H., Bian, G., Herbst-Gervason, C. J., Mori, T., Shinsky, S. A., Hou, A., Mu, X., Huang, M., Cheng, S., Deng, Z., Christianson, D. W., Abe, I., Liu, T.
Nature Commun., 11, Article number: 3958 (2020) Link | Open Access | Press Release | Press Release 2 | NC Focus
Biosynthesis of biscognienyne B involving an unprecedented cytochrome P450-dependent alkynylation
Lv, J.-M., Gao, Y.-H., Zhao, H., Awakawa, T., Liu, L., Chen, G.-D., Yao, X.-S., Hu, D., Abe, I., Gao, H.
Angew. Chem. Int. Ed., 59, 13531-13536 (2020) Link
Exploiting a C-N bond forming cytochrome P450 monooxygenase for C-S bond formation
Morita, I., Mori, T., Mitsuhashi, T., Hoshino, S., Taniguchi, Y., Kikuchi, T., Nagae, K., Nasu, N., Fujita, M., Ohwada, T., Abe, I.
Angew. Chem. Int. Ed., 59, 3988-3993 (2020) Link | Hot Paper | Frontispiece
Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea
Zhang, Y.-H., Li, Y.-F., Wang, Y., Tan, L., Cao, Z.-Q., Xie, C., Xie, G., Gong, H.-B., Sun, W.-Y., Ouyang, S.-H., Duan, W.-J., Lu, X., Ding, K., Kurihara, H., Hu, D., Zhang, Z.-M., Abe, I., He, R.-R.
Nature Commun., 11, Article number: 1473 (2020) Link | Open Access | Press Release
Molecular basis for the P450-catalyzed C–N bond formation in indolactam biosynthesis
He, F., Mori, T., Morita, I., Nakamura, H., Alblova, M., Hoshino, S., Awakawa, T., Abe, I.
Nature Chem. Biol., 15, 1206-1213 (2019) Link | Open Access | Press Release
Biomimetic synthesis of meroterpenoids by dearomatization-driven polycyclization
Powers, Z., Scharf, A., Yang, F., Cheng, A., Mitsuhashi, T., Barra, L., Taniguchi, Y., Kikuchi, T., Fujita, M., Abe, I., Porco, J. A. Jr.
Angew. Chem. Int. Ed., 58, 16141-16146 (2019) Link
Aminoacyl sulfonamide assembly in SB-203208 biosynthesis
Hu, Z., Awakawa, T., Ma, Z., Abe, I.
Nature Commun., 10, Article number: 184 (2019) Link | Open Access | Press Release
Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum: branched pathways encoded at two separate loci
Araki, Y., Awakawa, T., Matsuzaki, M., Cho, R., Matsuda, Y., Hoshino, S., Shinohara, Y., Yamamoto, M., Kido, Y., Inaoka, D. K., Nagamune, K., Ito, K., Abe, I., Kita, K.
Proc. Natl. Acad. Sci. USA, 116, 8269-8274 (2019) Link | Open Access | Press Release
Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution
Awakawa, T., Fujioka, T., Zhang, L., Hoshino, S., Hu, Z., Hashimoto, J., Kozone, I., Ikeda, H., Shin-ya, K., Liu, W., Abe, I.
Nature Commun., 9, Article number: 3534 (2018) Link | Open Access | Press Release
Structural and computational bases for dramatic skeletal rearrangement in anditomin biosynthesis
Nakashima, Y., Mitsuhashi, T., Matsuda, Y., Senda, M., Sato, H., Yamazaki, M., Uchiyama, M., Senda, T., Abe, I.
J. Am. Chem. Soc., 140, 9743-9750 (2018) Link
Computational studies on biosynthetic carbocation rearrangements leading to quiannulatene: initial conformation regulates biosynthetic route, stereochemistry, and type of skeleton
Sato, H., Mitsuhashi, T., Yamazaki, M., Abe, I., Uchiyama, M.
Angew. Chem. Int. Ed., 57, 14752-14757 (2018) Link
Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation
Matsuda, Y., Bai, T., Phippen, C. B. W., Nødvig, C. S., Kjærbølling, I., Vesth, T. C., Andersen, M. R., Mortensen, U. H., Gotfredsen, C. H., Abe, I., Larsen, T. O.
Nature Commun., 9, Article number: 2587 (2018) Link | Open Access | Blog | Faculty of 1000
Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage
Wang, G.-Q., Chen, G.-D., Qin, S.-Y., Hu, D., Awakawa, T., Li, S.-Y., Lv, J.-M., Wang, C.-X., Yao, X.-S., Abe, I., Gao, H.
Nature Commun., 9, Article number: 1838 (2018) Link | Open Access | Press Release | NC Collection
Molecular insights into the Mg2+-dependent allosteric control of indole prenylation by aromatic prenyltransferase AmbP1
Awakawa, T., Mori, T., Nakashima, Y., Zhai, R., Wong, C. P., Hillwig, M. L., Liu, X., Abe, I.
Angew. Chem. Int. Ed., 57, 6810-6813 (2018) Link
Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis
Nakashima, Y., Mori, T., Nakamura, H., Awakawa, T., Hoshino, S., Senda, M., Senda, T., Abe, I.
Nature Commun., 9, Article number: 104 (2018) Link | Open Access | Press Release
Unique chemistry of non-heme iron dependent enzymes in fungal biosynthetic pathway
Nakamura, H., Matsuda, Y., Abe, I.
Nat. Prod. Rep., 35, 633-645 (2018) Link | Front Cover
Two distinct substrate binding modes for the normal and reverse prenylations of hapalindoles by the prenyltransferase AmbP3
Wong, C. P., Awakawa, T., Nakashima, Y., Mori, T., Zhu, Q., Liu, X., Abe, I.
Angew. Chem. Int. Ed., 57, 560-563 (2018) Link
Molecular basis for the unusual ring reconstruction in fungal meroterpenoid biogenesis
Mori, T., Iwabuchi, T., Hoshino, S., Wang, H., Matsuda, Y., Abe, I.
Nature Chem. Biol., 13, 1066-1073 (2017) Link | Press Release
Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis
Lv, J.-M., Hu, D., Gao, H., Kushiro, T., Awakawa, T., Chen, G.-D., Wang, C.-X., Abe, I., Yao, X.-S.
Nature Commun., 8, Article number: 1644 (2017) Link | Open Access | Press Release | NC Collection
Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides
Zhang, L., Hashimoto, T., Qin, B., Hashimoto, J., Kozone, I., Kawahara, T., Okada, M., Awakawa, T., Ito, T., Asakawa, Y., Ueki, M., Takahashi, S., Osada, H., Wakimoto, T., Ikeda, H., Shin-ya, K., Abe, I.
Angew. Chem. Int. Ed., 56, 1740-1745 (2017) Link | Hot Paper | Frontispiece | Press Release
Discovery of key dioxygenases that diverged the paraherquonin and acetoxydehydroaustin pathways in Penicillium brasilianum
Matsuda, Y., Iwabuchi,T., Fujimoto, T., Awakawa,T., Nakashima, Y., Mori, T., Zhang, H., Hayashi, F., Abe, I.
J. Am. Chem. Soc., 138, 12671-12677 (2016) Link
Genome-based discovery of an unprecedented cyclization mode in fungal sesterterpenoids biosynthesis
Okada, M., Matsuda, Y., Mitsuhashi, T., Hoshino, S., Mori, T., Nakagawa, K., Quan, Z., Qin, B., Zhang, H., Hayashi, F., Kawaide, H., Abe, I.
J. Am. Chem. Soc., 138, 10011-10018 (2016) Link | JACS Spotlights
Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases
Mori, T., Zhang, L., Awakawa, T., Hoshino, S., Okada, M., Morita, H., Abe, I.
Nature Commun., 7, Article number: 10849 (2016) Link | Open Access | Press Release
Astellifadiene, a unique tetracyclic fungal sesterterpene: structure determination by an NMR-coupled crystalline sponge method and elucidation of its biosynthesis
Matsuda, Y., Mitsuhashi,T., Lee, S., Hoshino, M., Mori, T., Okada, M., Zhang, H., Hayashi, F., Fujita, M., Abe, I.
Angew. Chem. Int. Ed., 55, 5785-5788 (2016) Link | Press Release
An unusual chimeric diterpene synthase from Emericella variecolor and its functional conversion to a sesterterpene synthase by domain swapping
Qin, B., Matsuda, Y., Mori, T., Okada, M., Quan, Z., Mitsuhashi, T., Wakimoto, T., Abe, I.
Angew. Chem. Int. Ed., 55, 1658-1661 (2016) Link | Front Cover | Press Release
Biosynthesis of fungal meroterpenoids
Matsuda, Y., Abe, I.
Nat. Prod. Rep., 33, 26-53 (2016) Link | Open Access
Nature's way of making the sponge-derived cytotoxin
Wakimoto, T., Egami, Y., Abe, I.
Nat. Prod. Rep., 33, 751-760 (2016) Link | Open Access | Front Cover
Rational control of polyketide extender units by structure-based engineering of a crotonyl-CoA carboxylase/reductase in antimycin biosynthesis
Zhang, L., Mori, T., Zheng, Q., Awakawa, T., Yan, Y., Liu, W., Abe, I.
Angew. Chem. Int. Ed., 54, 13462-13465 (2015) Link | Press Release
Uncovering the unusual D-ring construction in terretonin biosynthesis by collaboration of a multifunctional cytochrome P450 and a unique isomerase
Matsuda, Y., Iwabuchi, T., Wakimoto, T., Awakawa, T., Abe, I.
J. Am. Chem. Soc., 137, 3393-3401 (2015) Link
Complete biosynthetic pathway of anditomin: nature's sophisticated synthetic route to a complex fungal meroterpenoid
Matsuda, Y., Wakimoto, T., Mori, T., Awakawa, T., Abe, I.
J. Am. Chem. Soc., 136, 15326–15336 (2014) Link | Front Cover | JACS Spotlights
Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont
Wakimoto, T., Egami, Y., Nakashima, Y., Wakimoto,Y., Mori, T., Awakawa,T., Ito, T., Kenmoku, H., Asakawa, Y., Piel, J., Abe, I.
Nature Chem. Biol., 10, 648-655 (2014) Link | News & Views | Press Release | Faculty of 1000
A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis
Awakawa, T., Zhang, L., Wakimoto, T., Hoshino, S., Mori, T., Ito, T., Ishikawa, J., Tanner, M. E., Abe, I.
J. Am. Chem. Soc., 136, 9910-9913 (2014) Link | Faculty of 1000
An environmental bacterial taxon with a large and distinct metabolic repertoire
Wilson, M. C., Mori, T., Rückert, C., Uria, A. R., Helf, M. J., Takada, K., Gernert, C., Steffens, U. A. E., Heycke, N., Schmitt, S., Rinke, C., Helfrich, E. J. N., Brachmann, A. O., Gurgui, C., Wakimoto. T., Kracht, M., Crüsemann, M., Hentschel, U., Abe, I., Matsunaga, S., Kalinowski, J., Takeyama, H., Piel, J.
Nature, 506, 58-62 (2014) Link | Open Access | News & Views | Press Release
Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis
Matsuda, Y., Awakawa, T., Wakimoto, T., Abe, I.
J. Am. Chem. Soc., 135, 10962-10965 (2013) Link
Multiplexing of combinatorial chemistry in antimycin biosynthesis expands the molecular diversity and utility
Yan Y., Chen, J., Zhang, L., Zheng, Q., Han, Y., Zhang, H., Awakawa, T., Abe, I., Liu, W.
Angew. Chem. Int. Ed., 52, 12308-12312 (2013) Link
Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase
Morita, H., Yamashita, M., Shi, S.-P., Wakimoto, T., Kondo, S., Kato, R., Sugio, S., Kohno, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 108, 13504-13509 (2011) Link
Cytotoxic tetramic acid derivative produced by a plant type III polyketide synthase
Wakimoto, T., Mori, T., Morita, H., Abe, I.
J. Am. Chem. Soc., 133, 4746-4749 (2011) Link
Furan fatty acid as an anti-inflammatory component from green-lipped mussel Perna canaliculus
Wakimoto, T., Kondo, H., Nii, H., Kimura, K., Egami, Y., Oka, Y., Yoshida, M., Kida, E., Ye, Y.-p., Akahoshi, S., Asakawa, T., Matsumura, K., Ishida, H., Nukaya, H., Tsuji, K., Kan, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 108, 17533-17537 (2011) Link
Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa
Morita, H., Wanibuchi, K., Nii, H., Kato, R., Sugio, S., Abe, I.
Proc. Natl. Acad. Sci. USA, 107, 19778-19783 (2010) Link
A structure-based mechanism for benzalacetone synthase from Rheum palmatum
Morita, H., Shimokawa, Y., Tanio, M., Kato, R., Noguchi, H., Sugio, S., Kohno, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 107, 669-673 (2010) Link
Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases
Abe, I., Morita, H.
Nat. Prod. Rep., 27, 809-838 (2010) Link
Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases
Itoh, T., Tokunaga, K., Matsuda, Y., Fujii, I., Abe, I., Ebizuka, Y., Kushiro, T.
Nature Chemistry, 2, 858-864 (2010) Link | News & Views | Faculty of 1000
Structure-based engineering of a plant type III polyketide synthase: formation of an unnatural nonaketide naphthopyrone
Abe, I., Morita, H., Oguro, S., Noma, H., Wanibuchi, K., Kawahara, N., Goda, Y., Noguchi, H., Kohno, T.
J. Am. Chem. Soc., 129, 5976-5980 (2007) Link
Structural insight into chain-length control and product specificity of pentaketide chromone synthase from Aloe arborescens
Morita, H., Kondo, S., Oguro, S., Noguchi, H., Sugio, S., Abe, I., Kohno, T.
Chemistry & Biology, 14, 359-369 (2007) Link
Enzymatic synthesis of cyclic triterpenes
Abe, I.
Nat. Prod. Rep., 24, 1311-1331 (2007) Link
Engineered biosynthesis of plant polyketides: chain length control in an octaketide-producing plant type III polyketide synthase
Abe, I., Oguro, S., Utsumi, Y., Sano, Y., Noguchi, H.
J. Am. Chem. Soc., 127, 12709-12716 (2005) Link
A plant type III polyketide synthase that produces pentaketide chromone
Abe, I., Utsumi, Y., Oguro, S., Morita, H., Sano, Y., Noguchi, H.
J. Am. Chem. Soc., 127, 1362-1363 (2005) Link
Mechanism and stereochemistry of enzymatic cyclization of 24,30-bisnor-2,3-oxidosqualene by recombinant β-amyrin synthase
Abe, I., Sakano, Y., Sodeyama, M., Tanaka, H., Noguchi, H., Shibuya, M., Ebizuka, Y.
J. Am. Chem. Soc., 126, 6880-6881 (2004) Link
Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3β-ol and bacchar-12-en-3β-ol by recombinant β-amyrin synthase
Abe, I., Sakano, Y., Tanaka, H., Lou, W., Noguchi, H., Shibuya, M., Ebizuka, Y.
J. Am. Chem. Soc., 126, 3426-3427 (2004) Link
Site-directed mutagenesis of benzalacetone synthase: the role of Phe215 in plant type III polyketide synthases
Abe, I., Sano, Y., Takahashi, Y., Noguchi, H.
J. Biol. Chem., 278, 25218-25226 (2003) Link
Enzymatic formation of an unnatural hexacyclic C35 polyprenoid by bacterial squalene cyclase
Abe, I., Tanaka, H., Noguchi, H.
J. Am. Chem. Soc., 124, 14514-14515 (2002) Link
Substrate specificity of chalcone synthase: enzymatic formation of unnatural polyketides from synthetic cinnamoyl-CoA analogs
Abe, I., Morita, H., Nomura, A., Noguchi, H.
J. Am. Chem. Soc., 122, 11242-11243 (2000) Link
Cyclization of (3S)29-methylidene-2,3-oxidosqualene by bacterial squalene:hopene cyclase: irreversible enzyme inactivation and isolation of an unnatural dammarenoid
Abe, I., Dang, T., Zheng, Y. F., Madden, B. A., Feil, C., Poralla, K., Prestwich, G. D.
J. Am. Chem. Soc., 119, 11333-11334 (1997) Link
Mechanism-based active site modification of oxidosqualene cyclase by tritium labeled 18-thia-2,3-oxidosqualene
Abe, I., Liu, W., Oehlschlagar, A. C., Prestwich, G. D.
J. Am. Chem. Soc., 118, 9180-9181 (1996) Link
Molecular cloning, characterization, and functional expression of rat oxidosqualene cyclase
Abe, I., Prestwich, G. D.
Proc. Natl. Acad. Sci. USA, 92, 9274-9278 (1995) Link
Inhibitors of squalene biosynthesis and metabolism
Abe, I., Tomesch, J. C., Wattanasin, S., Prestwich, G. D.
Nat. Prod. Rep., 11, 279-302 (1994) Link
Active site mapping of affinity labeled rat oxidosqualene cyclase
Abe, I., Prestwich, G. D.
J. Biol. Chem., 269, 802-804 (1994) Link
Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes
Abe, I., Rohmer, M., Prestwich, G. D.
Chem. Rev., 93, 2189-2206 (1993) Link
