Groups and Members
A01: Creation of Artificial Biosynthetic Machineries｜A02: Construction of Biological System for Mass-production｜A03 Structure and Function of Biosynthetic Machineries
Research Program A01: Creation of Artificial Biosynthetic Machineries
Name / Affiliation
Ikuro ABE
Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Research Project
The Next Generation Natural Products Chemistry by Rational Reprogramming of Biosynthetic Machineries
Name / Affiliation
Hiroaki SUGA
Professor, Graduate School of Science, The University of Tokyo
Research Project
In vitro Synthetic Biology for Pseudo-Natural Products
Name / Affiliation
Yoshimitsu HAMANO
Professor, Faculty of Bioscience, FUKUI Prefectural University
Research Project
Biosynthetic Redesign of Bioactive Small Compounds for Simultaneous Enhancement of Cell Membrane Permeability and Hydrophilicity
Name / Affiliation
Atsushi MINAMI
Associate Professor, Graduate School of Science, Hokkaido University
Research Project
Reprogramming Biosynthetic Machineries for the Development of Novel Biologically Active Polyketides
Research Program A02: Construction of Biological Systems for Mass Production
Name / Affiliation
Haruo IKEDA
Professor, Graduate School of Infection Control Sciences, Kitasato University
Research Project
Comprehensive Metabolic Analysis in the Secondary Metabolite Production of an Engineered Versatile Streptomyces Host
Name / Affiliation
Toshiyuki WAKIMOTO
Professor, Graduate School of Pharmaceutical Sciences, Hokkaido University
Research Project
Heterologous Production of Bioactive Metabolites derived from Uncultured Bacteria
Name / Affiliation
Kenji WATANABE
Professor, Department of Pharmaceutical Sciences, University of Shizuoka
Research Project
Genetic Indoctrination of Microorganism for Innovative Drug Discovery
Name / Affiliation
Daisuke UMENO
Professor, Department of Applied Chemistry, Chiba University
Research Project
Evolutionary Engineering of Robustness of the Synthetic Natural Product Pathways
Research Program A03: Structure and Function of Biosynthetic Enzymes
Name / Affiliation
Tadashi EGUCHI
Professor, Department of Chemistry, Tokyo Institute of Technology
Research Project
Mechanistic Enzymology of Biosynthetic Enzymes toward Metabolic Redesign for Unnatural Natural Products
Name / Affiliation
Tohru DAIRI
Professor, Faculty of Engineering, Hokkaido University
Research Project
Comprehension of Biosynthetic Machinery for Development of High-functional Biomolecules.
Name / Affiliation
Tomohisa KUZUYAMA
Professor, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Research Project
Innovation of Biosynthetic Machineries for Natural Products
Name / Affiliation
Mami YAMAZAKI
Professor, Graduate School of Pharmaceutical Sciences, Chiba University
Research Project
Designed Biosynthesis Based on Knowledge from the Evolution of Plant Specialized Metabolisms
A01: Creation of Artificial Biosynthetic Machineries｜A02: Construction of Biological System for Mass-production｜A03 Structure and Function of Biosynthetic Machineries
Research Program A01: Creation of Artificial Biosynthetic Machineries
Name / Affiliation
Min YAO
Professor, Faculty of Advanced Life Science, Hokkaido University
Research Project
TBuilding a Biosynthesis Pathway of Non-natural Adrenergic Drug
Name / Affiliation
Teigo ASAI
Associate Professor, Graduate School of Arts and Sciences, The University of Tokyo
Research Project
Production of Anti-cancer Active Pseudo-natural Products through Artificial Metabolic Pathway Built into Aspergillus oryzae
Name / Affiliation
Masahiro OKADA
Professor, Department of Material and Life Chemistry, Kanagawa University
Research Project
Redesign of Biosynthesis for Unnatural Sesterterpene Production
Name / Affiliation
Masanobu UCHIYAMA
Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Research Project
A Challenge for Comprehensive Search and “Re-design”the Biosynthetic Pathways Based on Theoretical Calculation
Name / Affiliation
Hiroki OGURI
Professor, Graduate School of Engineering, Tokyo University of Agriculture and Technology
Research Project
Chemo-enzymatic Synthesis of Multicyclic Alkaloids
Name / Affiliation
Fumitaka KUDO
Associate Professor, Department of Chemistry, Tokyo Institute of Technology
Research Project
Redesigning Biosynthetic Machineries of Antitumor Macrolide Antibiotics
Name / Affiliation
Hiroyuki MORITA
Professor, Institute of Natural Medicine, University of Toyama
Research Project
Discovering Plant-specific Novel Polyketide Cyclases for Engineering Useful Substances
Name / Affiliation
Fumihiro ISHIKAWA
Associate Professor, Faculty of Pharmacy, Kindai University
Research Project
A Chemoproteomics Approach for the Rational Design of Unnatural Natural Products
Name / Affiliation
Masahiro FUJIHASHI
Assistant Professor, Department of Chemistry, Graduate School of Science, Kyoto University
Research Project
Mining and Functional Improvement of Enzymes Based on the Crystal Structures of Novel Enzymes
Name / Affiliation
Eiji NAKATA
Associate Professor, Institute of Advanced Energy, Kyoto University
Research Project
Construction of Non-natural Biosynthetic System in vitro
Name / Affiliation
Kiyotake SUENAGA
Professor, Department of Chemistry, Faculty of Science and Technology, Keio University
Research Project
Studies on Biosynthesis and Production of Artificial Analogs of Marine Lipopeptides with Unique Chemical Structure
Name / Affiliation
Naoki KATO
Reseracher, RIKEN Center for Sustainable Resource Science
Research Project
Functional Analysis of Fsa2-family Diels-Alderases and Creation of New Decalin Derivatives with Unnatural Configurations
Name / Affiliation
Maiko UMEMURA
Researcher, National Institute of Advanced Industrial Science and Technology (AIST)
Research Project
Fungal RiPPs Library Construction for Design and Synthesis of Artificial Cyclic Peptides
Research Program A02: Construction of Biological Systems for Mass Production
Name / Affiliation
Taro OZAKI
Assistant Professor, Graduate School of Science, Hokkaido University
Research Project
Heterologous Production of Infection-specific Fungal Secondary Metabolites
Name / Affiliation
Jun-ichi MARUYAMA
Associate Professor, Department of Biotechnology, The University of Tokyo
Research Project
Development of Genome Editing-based Technology for Rapid and Multiple Gene Modification in Heterologous Production of Secondary Metabolites in Aspergillus oryzae
Name / Affiliation
Kazufumi YAZAKI
Professor, Research Institute for Sustainable Humanosphere, Kyoto University
Research Project
Redesign of Biosynthetic Machinery for Prenylated Polyphenols via Integration of Metabolic and Transport Engineering
Name / Affiliation
Satoru WATANABE
Assistant Professor, Department of Bioscience, Tokyo University of Agriculture
Research Project
Metabolic and Evolutional Engineering of Cyanobacteria for Effective Production of Strigolactone and its Derivatives
Name / Affiliation
Nobukazu SHITAN
Professor, Kobe Pharmaceutical University
Research Project
Development of Efficient Alkaloid Production System using Tolerance and Transport Proteins in Synthetic Biology
Name / Affiliation
Shunji TAKAHASHI
Researcher, RIKEN Center for Sustainable Resource Science
Research Project
Construction of Biosynthetic Platform Focused on Terpenoid Production using Streptomyces Host and Creation of Novel Secondary Metabolites
Name / Affiliation
Wataru KITAGAWA
Researcher, National Institute of Advanced Industrial Science and Technology (AIST)
Research Project
Development of a Reversed-evolved Host Microorganism for Bioproduction
Research Program A03: Structure and Function of Biosynthetic Enzymes
Name / Affiliation
Yuko CHO
Assistant Professor, Graduate School of Agricultural Science, Tohoku University
Research Project
Development of Basic Technique for the Search of the Toxin Biosynthetic Machinery and Genome Analysis of the Organism having Huge Genome
Name / Affiliation
Tomonobu TOYOMASU
Professor, Faculty of Agriculture, Yamagata University
Research Project
Evolution of Functions of Diterpene Cyclases in Rice
Name / Affiliation
Yohei KATSUYAMA
Associate Professor, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Research Project
Study on Biosynthetic Machinery of Nonribosomal Peptide Synthetase
Name / Affiliation
Futoshi TAUR
Associate Professor, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama
Research Project
Functional Re-design of the Biosynthetic Enzymes Producing Pharmacologically Active Plant Meroterpenoids based on Crystal Structure Analyses
Name / Affiliation
Hisashi HEMMI
Associate Professor, Graduate School of Bioagricultural Sciences, Nagoya University
Research Project
Machinery of Condensation Reactions between Isoprene Units that Generate the Structural Variety of Isoprenoid
Name / Affiliation
Hikaru SEKI
Associate Professor, Graduate School of Engineering, Osaka University
Research Project
Reconstruction of Plant-derived Rare Sesquiterpenoids Biosynthetic Pathways
Name / Affiliation
Shingo NAGANO
Professor, Graduate School of Engineering, Tottori University
Research Project
Biosynthetic Mechanism of Highly Strained Ladderane Lipids in Anammox Bacteria
Name / Affiliation
Kenji ARAKAWA
Associate Professor, Graduate School of Advanced Sciences of Matterialas, Hiroshima University
Research Project
Mechanistic Study and Biosynthetic Redesign of Silent Secondary Metabolites Produced by Rational Modification of Metabolic Pathway
Name / Affiliation
Nobutaka FUNA
Associate Professor, Department of Food and Nutritional Sciences, University of Shizuoka
Research Project
Dissecting Biosynthetic Machinery of Aromatic Polyketides for Functional Reconstitution in E. coli
Name / Affiliation
Tetsuro SHINADA
Professor, Graduate School of Science, Osaka City University
Research Project
Synthetic Studies of Acyclic Terpene Probes to Elucidate the Reaction Mechanism of Terpenoid Biosynthesis
Name / Affiliation
Isao FUJII
Professor, Iwate Medical University
Research Project
Functional and Structural Analyses of Eletrocyclization Enzymes Involved in Fungal Natural Product Biosynthesis
